美国密西西比大学医学中心,药理与毒理学，副教授;研究生院博士导师，湖南中医药大学医学院，百人计划学者，特聘教授，博士导师,湖南省2014年百人计划引进人才,目前担任湖南中医药大学中西医结合心脑疾病防治重点实验室主任.美国国家卫生研究院首席科学家，美国心脏学Fellow,美国及英国心脏学会基金评委，英国糖尿病学会基金评委,美国国家卫生研究院特别科学基金评委。国际<>杂志副主编。长期从事促血管生成素系统 (Angiopoietins/Tie-2)对新生的血管形成及心肌损伤修复的影响。在国际上首先发现并提出了 “糖尿病的新生血管不成熟稳定”的新颖观点, 该发现为糖尿病异常血管生成及糖尿病心肌病的治疗, 开发新的药物提供重要的实验基础。2011年至2013连续三届获得密西西比大学医学中心优秀科研成就奖。先后主持完成了美国心脏学会和美国国家卫生研究院(NIH)科研项目5项，担任主持人科研经费达到200万美元. 发表SCI论文30余篇。其中作为通信作者发表论文在国际著名杂志;<>杂志(影响因子8.474), ATVB杂志 (影响因子6.338),美国生理学杂志(影响因子4.012)以及 Laboratory Investigation杂志等.
教育学习经历:
1996/09-1999/10 湖南医科大学及美国南伊里诺依大学统招联合培养博士研究生
1987/09-1990/07 河南医科大学药理学专业研究生, 硕士
1980/09-1985/07 湖南医学院医疗系, 学士
学习工作经历
2015/01-现在 湖南中医药大学中西医结合心脑疾病防治重点实验室主任，博士导师
2011/01-现在 美国密西西比大学医学中心,药理与毒理学副教授,研究生院博士导师。
2005/10-2008/10 南华大学特聘教授，
2001/01-2010/10 美国著名大学范登堡大学医学中心,病理学助理教授及儿科学副教授.
1999/10-2001/01 美国著名大学范登堡大学医学中心博士后.
1990/07-1996/07 湖南衡阳医学院，药理与毒理学副教授. 药理学重点学科带头人，湖南
省青年骨干教师, 湖南省优秀教师.
1985/07-1987/07 湖南衡阳医学院，药理与毒理学助理教授。
获奖情况
1993年湖南省优秀教学成果一等奖
1993年中华人民共和国教育部优秀教学成果二等奖
1997年湖南省优秀教学成果奖三等奖
1999年湖南省卫生厅科技进步成果二等奖，
1999年湖南省科技部科技成果奖三等奖
2011年美国密西西比大学医学中心优秀科研成就铜牌奖
2012年美国密西西比大学医学中心优秀科研成就银牌奖
2013年美国密西西比大学医学中心优秀科研成就金牌奖
个人专长: 心血管药理，糖尿病心肌病变，干细胞，血管形成因子对于心肌梗塞的修复，基因治疗，转基因或基因敲除，自由基及线粒体功能研究
主持或参加科研项目及人才计划项目情况
主持(参与)过的主要项目
2010/7-2015/11 美国国家卫生研究院 一百五十五万美元 主持人
2006/4-2010/3 美国国家卫生研究院 四十一万美元 主持人
2005/7-2007/6 美国心脏学会 一十一万美元 主持人
2005/4-2009/3 美国国家卫生研究院 一百四十五万美元 合作者
2001/6-2005/5 美国国家卫生研究院 一百五十五万美元 合作者
1992/7-1994/7 湖南省自然科学基金 2万人民币 主持人
1992/10-1996/10 中国国家自然科学基金 6万人民币 主持人
项目
1R01HL102042-01A1 07/15/2010-11/30/2015
NIH/NHLBI
Title: Regulation of vascular maturation/regression in diabetes
Total Budget: $1,550,000
Principal Investigator: Jian-Xiong Chen
1R21DK074995-01 04/01/06-03/31/2010
NIH/NIDDK
Title: Functional Role of Angiopoietin-2 in Diabetic Heart
Total Budget: $415,495
PI: Jian-Xiong Chen (65% effort)
0565196B (PI Dr. Jian-Xiong Chen) 07/01/05-06/30/07
American Heart Association
Total Budget: $110, 000
Title: Angiopoietins/Tie-2 and Diabetic Impaired Myocardial Angiogenesis
PI: Dr. Jian-Xiong Chen (25% effort)
R01 HL075511-01 (PI Dr. Judy Aschner) 04/01/05-03/31/09
NIH/NHLBI
Total Budget: $1,455,911
Title: Hsp90/Client Protein Interactions in the Newborn Lung
Role in Project: Co-investigator (25% effort).
R01 HL 49530 (PI, Meyrick) 06/01/00 - 05/31/05
NIH/NHLBI
Total Budget: $1,550,000
Title: Effects of Hypoxia on the Coronary Microcirculation
Role in Project: Co-investigator (85% effort).
发表论文 (通信作者发表论文*)
1. Wan Y, Weng SA, Chen JX, Wu HX, Cao YS. Effects of estradiol on asthma of guinea pigs and its relationship to beta-adrenergic receptors. Chinese Pharmacological Bulletin, 1993, 9(4):295-297.
2. Chen JX, Wu HX and Wan You. The role of endotoxin in the bronchial hyper-reactivity formation. Chinese Journal of Medicine, 1994, 74(1):38-40.
3. Liao DF, Lu N, Lei LS, Yu L, Chen JX. Effects of gypenosides on mouse splenic lymphocyte transformation and DNA polymerase II activity in vitro. Acta Pharmacological Sin. 16(4):322-4.1995
4. Chen JX, Chen WZ, Hung HL, Chen LX, Xie ZZ, Zhu PY. Protective effects of Ginkgo biloba extract against lysophosphatidylcholine induced endothelium cell damage. Acta Pharmacological Sin. 19(4):359-363,1998.
5. Li LX, Chen JX, Liao DF, Yu L. Probucol inhibits oxidized-low density lipoprotein induced adhesion of monocytes to endothelial cells by reducing P-selectin synthesis in vitro. Endothelium. 6:1-8, 1998.
6. Su CY, Chong KY, Chen JX, Ryter SW, Lai CC. A physiological relevant hyperthermia selectively activates constitutive Hsp70 in H9c2 cardiac myoblasts and confers oxidative protection. J Mol Cell Cardiol. 31:845-855, 1999. PMID: 10329212.
7. Chen JX*, Zeng H, Chen X, Su CY, Lai CC. Induction of heme oxygenase-1 by Ginkgo biloba extract but not its tepernoids constituents partially mediated its protective effect against lysophosphatidylcholine-induced damage. Pharmacological Research. 43(1):63-69, 2001, PMID: 11207067.
8. Chen JX, Berry LC, Christman BW, Tanner M, Myers PR, Meyrick BO. NO regulates LPS-stimulated cyclooxygenase gene expression and activity in pulmonary artery endothelium. Am J Physiology. 280:L450-457, 2001, PMID: 11159028.
9. Chen JX, Berry LC, Tanner M, Myers PR, Meyrick BO. Nitric oxide donors regulate nitric oxide synthase in bovine pulmonary artery endothelium. J Cellular Physiology. 186:116-123, 2001, PMID: 11147806.
10. Chen JX, Berry LC, Meyrick BO. Glutathione mediates LPS-stimulated COX-2 expression via early transient P42/44 activation. J Cellular Physiology.197:86-93, 2003, PMID: 12942544.
11. Chen JX, Lawrence ML, Cunningham G, Christman BW, Meyrick B. Hsp90 and Akt Modulate Ang-1 Induced Angiogenesis via NO in Coronary Artery Endothelium. J Appl Physiol. 96: 612-620, 2004, PMID: 14555685.
12. Chen JX, Meyrick BO. Hypoxia Increases Hsp90 Binding to eNOS via a PI3Kinase-Akt Pathway in Porcine Coronary Artery Endothelium. Lab Invest. 84(2):182-190, 2004, PMID: 14661033.
13. Chen JX, Chen Y, DeBusk L, Lin W, Lin PC. Dual functional roles of Tie-2/angiopoietin in TNF-alpha-mediated angiogenesis. Am J Physiol Heart Circ Physiol. 287(1):H187-95, 2004, PMID: 15210451.
14. Chen JX, Zeng H, Lawrence ML, Sadikot RT, Blackwell TS, Meyrick B. Role of NADPH oxidase-derived reactive oxygen species (ROS) in angiopoietin-1-induced angiogenesis. Am J Physiol Heart Circ Physiol, 291:1563-1572, 2006, PMID: 16679392.
15. Pei J, Yan PK, Chen JX, Zhu BY, Lei XY, Yin WD, Liao DF. High-density lipoprotein 3 inhibits oxidized low- density lipoprotein-induced apoptosis via promoting cheolesterol efflux in RAW264.7 cells. Acta Pharmacological Sin. 27(2):151-7, 2006.
16. Chen JX*, Zeng H, Qin-Hui Tuo, Heidi Yu, Meyrick B, Judy Aschner. NADPH oxidase mediates myocardial Akt, ERK1/2 activation and angiogenesis after hypoxia/reperfusion. Am J Physiol Heart Circ Physiol, 292:H1664-1674, 2007, PMID: 17220182. PMCID: PMC2383323.
17. Tuo QH, Zeng H, Stinnett A, Yu HD, Aschner JL, Chen JX*. Critical role of angiopoietins/Tie-2 in hyperglycemic exacerbation of myocardial infarction and impaired angiogenesis. Am J Physiol Heart Circ Physiol, 294(6):H2547-57, 2008, PMID: 18408125.
18. Chen JX*, Stinnett A. Disruption of Ang-1/Tie-2 signaling contributes to the impaired myocardial vascular maturation and angiogenesis in type II diabetic mice. Arterioscler Thromb Vasc Biol, 28:1606-1613, 2008. PMID: 18556567.
19. Chen JX*, Stinnett A. Critical role of the NADPH oxidase subunit p47phox on vascular TLR expression and neointimal lesion formation in high fat diet-induced obesity. Lab Invest, 88:1316-1328; 2008. PMID: 18779779.
20. Chen JX*, Stinnett A. Ang-1 gene therapy inhibits hypoxia-inducible factor-1alpha (HIF-1alpha)-prolyl-4-hydroxylase-2, stabilizes HIF-1alpha expression, and normalizes immature vasculature in db/db mice. Diabetes, 57(12):3335-43; 2008. PMID: 18835934. PMCID: PMC2584141
21. Tuo QH, Xiong GZ, Zeng H, Yu HD, Sun SW, Ling HY, Zhu BY, Liao DF, Chen JX*. Angiopoietin-1 protects myocardial endothelial cell function blunted by angiopoietin-2 and high glucose condition. Acta Pharmacol Sin,32(1):45-51. 2011. PMID: 21113176
22. Chen JX*, Tuo QH, Liao DF, Zeng H. Inhibition of protein tyrosine phosphatase improves impaired angiogenesis via enhancing Ang-1/Tie-2 signaling in diabetes. Experimental Diabetes Research, 2012;2012:e836759 PMID:22454630
23. Chen JX*, Zeng H, Reese J, Aschner JL, Barbara Meyrick. Overexpression of angiopoietin-2 impairs myocardial angiogenesis and exacerbates cardiac fibrosis in the diabetic db/db mouse model. Am J Physiol Heart Circ Physiol, 2012;302(4):H1003-12. PMID:22180648
24. Zeng H, Li L, Chen JX*. Overexpression of Angiopoietin-1 increases CD133+/c-kit+ cells and reduces myocardial apoptosis in db/db mouse infarcted hearts. PLoS One. 2012;7(4):e35905. PMID:22558265
25. Li L, Zeng H, Chen JX*. Apelin-13 increases myocardial progenitor cells and improves repair of post-myocardial infarction. Am J Physiol Heart Circ Physiol, 2012:303 (5): H605-18. PMID:22752632
26. Chen JX, O"Mara PW, Poole SD, Brown N, Ehinger NJ, Slaughter JC, Paria BC, Aschner JL, Reese J. Isoprostanes as physiological mediators of transition to newborn life: Novel mechanisms regulating patency of the term and preterm ductus arteriosus. Pediatric Research 72: 122-128, 2012.
27. Li L, Zeng H, Hou X, He X, Chen JX*。 Myocardial Injection of Apelin-Overexpressing Bone Marrow Cells Improves Cardiac Repair via Upregulation of Sirt3 after Myocardial Infarction. PLoS ONE. 2013; 8(9): e71041. PMID:24039710
28. Zeng H, He X, Hou X, Li L, Chen JX*. Apelin gene therapy increases myocardial vascular density and ameliorates diabetic cardiomyopathy via upregulation of Sirtuin 3. Am J Physiol Heart Circ Physiol. 2014;306(4):H585-97. PMID:24363305
29. Zeng H, Li L, Chen JX*. Loss of sirt3 limits bone marrow cell-mediated angiogenesis and cardiac repair in post-myocardial infarction. PLoS One. 2014;9(9):e107011. PMID:25192254
30. Hou X, Zeng H, He X, Chen JX*. Sirt3 is essential for apelin-induced angiogenesis in post-myocardial infarction of diabetes. J Cell Mol Med. 2015;19(1):53-61. doi: 10.1111/jcmm
31. Zeng H, Chen JX*. Conditional knockout of prolyl hydroxylase domain protein 2 attenuates high fat-diet-induced cardiac dysfunction in mice. PLoS One. 2014;9(12):e115974. doi: 10.1371/journal.pone.0115974.
32. Zeng H,Vaka VR , He X,Booz WG, Chen JX*. High Fat Diet Induces Cardiac Remodeling and Dysfunction: Assessment of the Role Played by SIRT3 Loss. Journal of Cellular and Molecular Medicine 2015 in press
专著(Book Chapters):
Chen JX, Zeng H, Chen X, Su CY, Lai CC. Heme oxygenase, Ginkgo biloba extract and its terpenoids protect myocytes against oxidative injury. In: Heme Oxygenase in Biology and Medicine. NG Abraham, ed., 2002, pp. 399-408.
会议摘要(Abstracts):
Li L, Zeng H, Chen jx. Apelin-13 Increases Myocardial Progenitor Cells and Improves Myocardial Remodeling of Post-myocardial Hypertension. 2012;60:A32
Chen JX. Regulation Of Sirt3 And Autophagy By Bone Marrow Cells Therapy Improves Cardiac Repair In Post-myocardial Infarction Mice. Circulation Research. 2012;111:e386
Li L, Zeng H, Chen jx. Apelin Reduces Myocardial Infarction Size and Promotes Angiogenesis by Increasing SDF-1/CXCR4 and AKT/eNOS/VEGF pathways Circulation Research. 2012;111:A145
Zeng H, Chen JX. Ang-1 reduces myocardial infarction via upregulation of SDF-1/CXCR4 and recruiting hematopoietic progenitor cells in the diabetic db/db mouse model. Circulation. 2011.
Chen JX, Overexpression of angiopoietin-2 promotes myocardial fibrosis and rarefaction in diabetic db/db mouse model. FASEB JOURNAL 2011. (Platform Presentation)
Tuo, QH; Chen, JX; Liao, DF. Angiopoietin-1 protects ischemic heart exacerbated by hyperglycemia via increase of angiogenesis. JOURNAL OF PHARMACOLOGICAL SCIENCES; 260P-260P, 2010 (Poster)
Chen, JX; Yu, H; Tuo, Q. Inhibition of protein tyrosine phosphatase improves hyperglycemic impaired angiogenesis. CIRCULATION, 16: 25-25; 2007 (Poster)
Chen, JX; Yu, H; Tuo, QH. Leptin stimulates angiogenesis in myocardial endothelial cells: Involvement of p47phox NADPH oxidase. FASEB JOURNAL 21: A180-A180; 2007. (Platform Presentation)
Tuo,QH; Yu,H; Chen, JX. High glucose blunts angiopoietin-1 (Ang-1)-induced angiogenesis in myocardial endothelial cells via impairment of Akt and eNOS phosphorylation. FASEB JOURNAL 21: A130-A131; 2007. (Platform Presentation)
Chen, JX; Zeng, H; Meyrick, B. Hypoxia/reoxygenation-induced myocardial angiogenesis: Role of NADPH oxidase derived reactive oxygen species (ROS)
CIRCULATION 114: 155-155; 2006. (Platform Presentation)
Chen, JX; Zeng, H; Lawrence, ML, et al. Role of NADPH oxidase-derived reactive oxygen species (ROS) in angiopoietin-1-induced angiogenesis
FASEB JOURNAL 18: A385-A385; 2004. (Platform Presentation)
Chen,JX; Meyrick,B. Hypoxia increases heat shock protein 90 binding (Hsp90) to endothelial nitric oxide synthase (eNOS) via a P13-Akt pathway in porcine coronary artery endothelium (PCAEC) . FASEB JOURNAL 17 : A805-A805; 2003 (Platform Presentation)
Oral Presentations at National Scientific Meetings:
Title: Hypoxia increases heat shock protein 90 binding (Hsp90) to endothelial nitric oxide synthase (eNOS) via a P13-Akt pathway in porcine coronary artery endothelium (PCAEC). Experimental Biology Meeting; San Diego, 2003
Title: Role of NADPH oxidase-derived reactive oxygen species (ROS) in angiopoietin-1-induced angiogenesis. Experimental Biology Meeting; Washington DC, 2004
Title: Hypoxia/reoxygenation-induced myocardial angiogenesis: Role of NADPH oxidase derived reactive oxygen species (ROS); American Heart Association Meeting, Chicago, 2006
Title: Leptin stimulates angiogenesis in myocardial endothelial cells: Involvement of p47phox NADPH oxidase. Experimental Biology Meeting; Washington DC, 2007
Title: High glucose blunts angiopoietin-1 (Ang-1)-induced angiogenesis in myocardial endothelial cells via impairment of Akt and eNOS phosphorylation. Experimental Biology Meeting; Washington DC, 2007
Title: Sirt3 is essential for apelin-gene therapy mediated cardiac repair in post-myocardial infarction of diabetes. High blood pressure Research Scientific sessions: 09/14/2014.
