简介：李朝辉，教授，博士生导师。现任郑州大学化学学院副院长、绿色催化中心副主任、生命分析化学研究所所长。兼任河南省功能分子绿色构建与生物分析国际联合实验室执行主任、郑州大学第一附属医院化学生物学与临床应用研究所执行主任、郑州市功能纳米材料与医学诊疗重点实验室主任、Analytica Chimica Acta编委、Chinese Chemical Letters编委、Molecules编委、《集成技术》编委、Journal of Analysis and Testing青年编委、《轻工学报》青年编委等，现为中国化学会高级会员、中国抗癌协会会员、河南省化学会常务理事、河南省普通高等学校化学专业教学指导委员会委员、全国大学生化学实验创新设计大赛华中赛区竞赛委员会副主任委员。荣获河南省科学技术进步一等奖、河南省自然科学三等奖、河南省教育厅科技成果一等奖、河南省教育厅学术技术带头人、河南省高等学校青年骨干教师等荣誉奖励多项。
联系方式：
邮箱：zhaohui.li@zzu.edu.cn
学习经历：
2001.09-2007.03 湖南大学，分析化学专业，博士
1997.09-2001.06 湖南大学，材料科学与工程专业，学士
工作经历：
2012.12 至今 郑州大学，教授
2011.08-2012.11 郑州大学，讲师
2009.08-2011.04 美国太平洋西北国家实验室（PNNL），博士后
2007.03-2009.08 美国塔夫茨大学（Tufts University），博士后
研究方向：
荧光纳米探针精准制备及其生命分析应用研究、数字式单分子检测技术及其临床应用研究、现场快速检测技术及其试剂盒研发、癌症等重大慢病早期预警及疗效评估研究。
主持项目：
主持承担国家自然科学基金面上项目、国家自然科学基金青年基金、教育部留学回国人员科研启动基金、人社部留学人员科技活动项目择优资助以及企业横向等科研项目20余项。部分项目信息如下：
Ÿ 国家自然科学基金面上项目：碳点脂滴靶向性的定量构效关系研究及其在肝脏脂质代谢紊乱监测中的应用，54万元，主持
Ÿ 国家自然科学基金面上项目：基于逆合成分析的荧光碳点精准制备及其细胞成像应用研究，66万元，主持
Ÿ 国家自然科学基金青年基金：基于荧光纳米颗粒及试纸条对痕量细菌进行快速测定的研究，25万元，主持
Ÿ 河南省科技研发计划联合基金重点项目：基于数字式单分子检测体系的肺腺癌血液蛋白标志物演变规律的研究，80万元，主持
Ÿ 河南省高校科技创新团队：功能纳米材料的精准构筑与生命分析应用，100万元，主持
Ÿ 郑州市协同创新重大专项：肺癌标志物高灵敏检测技术平台及其试剂盒研发及应用，2000万元，主持
代表论文：
从事研究工作以来，在Chemical Society Reviews，Journal of the American Chemical Society，CCS Chemistry，Advanced Functional Materials, Light: Science & Applications Analytical Chemistry，Small，ACS Sensors， Advanced Healthcare Materials，ACS Applied Materials & Interfaces, Biosensors and Bioelectronics, Carbon, Chemical Communication，Sensors & Actuators B: Chemical, Nanoscale, NanoscaleHorizons，Theranostics， Chinese Chemical Letters等学术刊物上发表SCI论文200余篇，授权中国发明专利30余项，参编英文学术专著4部，开发40余个生物标志物检测试剂盒用于癌症、阿尔兹海默等重大疾病的早期预警与疗效评估，部分已推广到临床应用研究。近年来部分代表性论文如下：
Ÿ YuanqiangSun, Pengjuan Sun,Lingbo Qu,Zhaohui Li, Wei Guo.Naturalflavylium-inspiredfar-red to NIR-IIdyes andtheirapplications asfluorescentprobes forbiomedicalsensing.Chemical Society Reviews,2022, 51, 7170-7205.
Ÿ Jingyu Hu, Yuanqiang Sun, Xin Geng, Junli Wang, Yifei Guo, Lingbo Qu, Ke Zhang,Zhaohui Li. High-fidelity carbon dots polarity probes: revealing the heterogeneity of lipids in oncology.Light: Science & Applications,2022, 11, 1555-1564.
Ÿ Xin Geng, Yifei Guo, Ying Wang, Yongxin Zhai, Beining Xu, Lingbo Qu,Zhaohui Li. Revealing the adverse effects of trace amount broad-spectrum antimicrobial: a direct and sensitive visualization method based on carbon nanoprobe. Advanced Functional Materials,2022, DOI:10.1002/adfm.202206753.
Ÿ Yanan Wu, Yating He, Miaomiao Han, Di Zhao, Bojun Liu, Kun Yuan, Hongzhi Sun, Hongmin Meng,Zhaohui Li. Dual-miRNA-propelled 3D DNA walker for highly specific and rapid discrimination of breast cancer cell subtypes in clinical tissue samples.CCS Chemistry,2022,DOI: 10.31635/ccschem.022.202202051.
Ÿ Kun Yuan, Hongmin Meng, Yanan Wu, Juan Chen, Hui Xu, Lingbo Qu, Lele Li,Zhaohui Li. Extracellular milieu and membrane receptor dual-driven DNA nanorobot for accurate in vivo tumor imaging.CCS Chemistry,2021, 3, 1679-1691.
Ÿ Minmin Yan, Deming He, Lishen Zhang, Pengjuan Sun, Yuanqiang Sun, Lingbo Qu,Zhaohui Li. Explorations into the meso-substituents BODIPY-based fluorescent probes for biomedical sensing and imaging. TrAC Trends in Analytical Chemistry,2022, DOI: 10.1016/j.trac.2022.116771.
Ÿ Meng Zhang, Ningning Wang,Zhaohui Li. Recent advances in chromophore-assembled upconversion nanoprobes for chemo/biosensing.TrAC Trends in Analytical Chemistry,2022, DOI: 10.1016/j.trac.2022.116602.
Ÿ Jingyu Hu, Yifei Guo, Xin Geng, Junli Wang, Sen Li, Yuanqiang Sun, Lingbo Qu,Zhaohui Li. Tuning asymmetric electronic structure endows carbon dots with unexpected huge stokes shift for high contrast in vivo imaging,Chemical Engineering Journal,2022, 466, 136928.
Ÿ Jingyu Hu, Ran Yang, Haoyue Qin,Yuanqiang Sun, LingboQu,Zhaohui Li. Spying on the polarity dynamics during wound healing of zebrafish by using rationally designed carbon dots. Advanced Healthcare Materials,2021, 10, 2002268.
Ÿ Juan Chen, Mingyue Xie, Mingqing Shi, Kun Yuan, Yanna Wu, Hong-Min Meng, Ling-Bo Qu,Zhaohui Li. Spatial confinement-drived double accelerated DNA cascade reaction for ultrafast and highly sensitive in situ monitoring exosomal miRNA and exosomes tracing.Analytical Chemistry,2022, 94(4), 2227-2235.
Ÿ Zengqiang Liang, Yuan-Qiang Sun, Ruihong Duan, Ran Yang, Ling-Bo Qu, Ke Zhang,Zhaohui Li. Low polarity triggered basic hydrolysis of coumarin as an and logic gate for broad-spectrum cancer diagnosis.Analytical Chemistry,2021, 93, 12434-12440.
Ÿ Yanan Wu, Zhijun Li, Mingqing Shi, Kun Yuan, Hong-Min Meng, Ling-Bo Qu,Zhaohui Li. Programmable DNAzyme computing for specific in vivo imaging: intracellular stimulus-unlocked target sensing and signal amplification.Analytical Chemistry,2021, 93, 12456-12463.
Ÿ Yan Song, Hongxing Zhang, Xia Wang, Xin Geng, Yuanqiang Sun, Jing Liu,Zhaohui Li. One stone, three birds: pH triggered transformation of aminopyronine and iminopyronine based lysosome targeting viscosity probe for cancer visualization.Analytical Chemistry,2021, 93, 1786-1791.
Ÿ Zengqiang Liang, Yuanqiang Sun, Huajin Zeng, Kai Sun, Ran Yang,Zhaohui Li, Ke Zhang, Xiaolan Chen, Lingbo Qu. Simultaneous detection of human serum albumin and sulfur dioxide in living cells based on a catalyzed michael addition reaction.Analytical Chemistry,2020, 92(24), 16130–16137.
Ÿ Xin Geng, Yuanqiang Sun, Yifei Guo, Yanmin Zhao, Ke Zhang, Lehui Xiao, Lingbo Qu, andZhaohui Li. Fluorescent carbon dots for in situ monitoring of lysosomal ATP levels.Analytical Chemistry,2020, 92(11), 7940-7946.
Ÿ Haifang Liu, Jie Yang,Zhaohui Li, Lehui Xiao, Aaron Albert Aryee, Yuanqiang Sun Ran Yang, Hongmin Meng, Lingbo Qu, Yuehe Lin, and Xiaobing Zhang. Hydrogen-bond induced emission of carbon dots for wash-free nucleus imaging.Analytical Chemistry,2019, 91, 9259-9265.
Ÿ Xinxin Shi, Hongmin Meng, Yuanqiang Sun, Lingbo Qu, Yuehe Lin,Zhaohui Li, Dan Du. Far-red and near-infrared carbon dots: preparation and applications in biotechnology.Small,2019, 1901507.
Ÿ Xin Geng, Yuanqiang Sun,Zhaohui Li, Ran Yang, Yanmin Zhao, Yifei Guo, Ying Wang, Siyu Lu and Lingbo Qu. Retrosynthesis of tunable fluorescent carbon dots for precise long-term mitochondrial tracking.Small,2019, 1901517.
