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孙远强


孙远强,理学博士,副教授,硕士生导师,郑州大学青年拔尖人才,河南省青年托举人才。主要从事荧光探针与生物医学传感的研究。开发了氯代香豆素半花菁、氯代吡啰红、香豆素-花色素等新型荧光染料,将有机逆合成分析理念引入荧光碳点的理性设计构建中。主持国家自然科学基金青年基金、中国博士后基金特别资助、中国博士后基金一等资助、河南省博士后基金科研项目一等资助、河南省青年人才托举工程、河南省科技攻项目、郑州市高新区创新创业团队项目共7项。在Chem. Soc. Rev.、J. Am. Chem. Soc.、Angew. Chem. Int. Ed.、Coordin. Chem. Rev.、Anal. Chem.、Chem. Commun.、Nanoscale、Small、Chinese Chem. Lettt.等杂志发表论文七十余篇,被引用4100余次,h影响因子34。单篇最高引用491次,被引用100次以上论文13篇。获得“山西省科学技术奖”自然科学类二等奖(4/6)1项,“河南省科学技术奖”自然科学奖三等奖(2/6)1项,河南省教育厅科技成果一等奖(2/6)1项。在癌症诊断、食品安全快速检测领域授权国家发明专利33项。

联系方式:sunyq@zzu.edu.cn

学习经历:

2011/09-2016/07,山西大学,化学化工学院,博士,导师:郭炜教授

2004/09-2008/06,山西大学,化学化工学院,学士

工作经历:2017/01-至今,郑州大学, 化学学院,教师

研究方向:荧光探针开发与生物医学传感应用,食品安全快速检测

主持项目:1.基于邻位硼酸催化点击反应的半胱氨酸和同型半胱氨酸新型有机荧光探针及生物成像研究,国家自然科学基金青年基金,主持

2.程序传感β-淀粉样蛋白、二氧化硫和双氧水的荧光探针,中国博士后科学基金特等资助,主持

3.基于芳基酮醛的半胱氨酸有机荧光探针及生物成像研究,中国博士后科学基金一等资助,主持

4.基于花色素的β-淀粉样蛋白荧光探针及其在阿尔茨海默病早期检测中的应用,河南省青年人才托举工程,主持

5.基于端基炔酮的半胱氨酸和同型半胱氨酸荧光探针及生物成像研究,河南省博士后科研项目一等资助,主持

6.特异性检测γ-氨基丁酸(GABA)受体的荧光探针及其在肝癌诊断中的应用,河南省重点研发与推广专项,主持

代表论文:

(1) Sun, Y.; Sun, P.; Li, Z.; Qu, L.; Guo, W. Natural Flavylium-Inspired Far-Red to NIR-II Dyes and Their Applications as Fluorescent Probes for Biomedical Sensing.Chem. Soc. Rev. 2022.

(2) Zhang, H.; Liu, J.; Sun, Y.-Q.; Liu, M.; Guo, W. Carbon–Dipyrromethenes: Bright Cationic Fluorescent Dyes and Potential Application in Revealing Cellular Trafficking of Mitochondrial Glutathione Conjugates.J. Am. Chem. Soc. 2020,142 (40), 17069–17078.

(3) Sun, Y.; Sun, P.; Guo, W. Fluorescent Probes for Iron, Heme, and Related Enzymes.Coordination Chemistry Reviews 2021,429, 213645.

(4) Meso-Substituented Pyronine: Colorful Emission and Versatile Platform for the Rational Design of Fluorescent Probes.Coordination Chemistry Reviews 2022,461, 214507.

(5) Yan, M.; He, D.; Zhang, L.; Sun, P.; Sun, Y.; Qu, L.; Li, Z. Explorations into the Meso-Substituted BODIPY-Based Fluorescent Probes for Biomedical Sensing and Imaging.TrAC Trends in Analytical Chemistry 2022,157, 116771.

(6) Geng, X.; Sun, Y.; Guo, Y.; Zhao, Y.; Zhang, K.; Xiao, L.; Qu, L.; Li, Z. Fluorescent Carbon Dots for in Situ Monitoring of Lysosomal ATP Levels.Anal. Chem. 2020,92 (11), 7940–7946.

(7) Liang, Z.; Sun, Y.; Duan, R.; Yang, R.; Qu, L.; Zhang, K.; Li, Z. Low Polarity-Triggered Basic Hydrolysis of Coumarin as an AND Logic Gate for Broad-Spectrum Cancer Diagnosis.Anal. Chem. 2021,93 (36), 12434–12440.

(8) Liang, Z.; Sun, Y.; Zeng, H.; Sun, K.; Yang, R.; Li, Z.; Zhang, K.; Chen, X.; Qu, L. Simultaneous Detection of Human Serum Albumin and Sulfur Dioxide in Living Cells Based on a Catalyzed Michael Addition Reaction.Anal. Chem. 2020,92 (24), 16130–16137.

(9) Liu, H.; Yang, J.; Li, Z.; Xiao, L.; Aryee, A. A.; Sun, Y.; Yang, R.; Meng, H.; Qu, L.; Lin, Y.; Zhang, X. Hydrogen-Bond-Induced Emission of Carbon Dots for Wash-Free Nucleus Imaging.Anal. Chem. 2019,91 (14), 9259–9265.

(10) Song, Y.; Zhang, H.; Wang, X.; Geng, X.; Sun, Y.; Liu, J.; Li, Z. One Stone, Three Birds: PH Triggered Transformation of Aminopyronine and Iminopyronine Based Lysosome Targeting Viscosity Probe for Cancer Visualization.Anal. Chem. 2021,93 (3), 1786–1791.

(11) Wang, L.; Liu, J.; Zhao, S.; Zhang, H.; Sun, Y.; Wei, A.; Guo, W. Fluorescence Imaging of Hypochlorous Acid and Peroxynitrite in Vitro and in Vivo with Emission Wavelength beyond 750 Nm.Chem. Commun. 2020,56 (56), 7718–7721.

(12) Hu, J.; Guo, Y.; Geng, X.; Wang, J.; Li, S.; Sun, Y.; Qu, L.; Li, Z. Tuning Asymmetric Electronic Structure Endows Carbon Dots with Unexpected Huge Stokes Shift for High Contrast in Vivo Imaging.Chemical Engineering Journal 2022,446, 136928.

(13) Liu, H.; Liu, J.; Zhang, S.; Chen, Y.; Zhang, J.; Sun, Y.; Zheng, Z.; Hu, S.; Li, Z.; Tang, W. Spying on the Peroxynitrite Fluctuation during Hearing Loss Enabled by Rationally Designed Fluorescent Carbon Dots.Chemical Engineering Journal 2023,452, 139024.

(14) Zhang, J.; Li, Y.; Hu, J.; Sun, Y.; Yang, R.; Li, Z.; Qu, L. Rapid Colorimetric and Ratiometric Fluorescence Method for On-Site Detection and Visualization of Phosgene by Amino-Functionalized Carbon Dot-Based Portable Droplet System.Chemical Engineering Journal 2022, 139173.

(15) Guo, Y.; Sun, Y.; Li, Z.; Feng, S.; Yang, R.; Qu, L. Detection, Detoxification, and Removal of Multiply Heavy Metal Ions Using a Recyclable Probe Enabled by Click and Declick Chemistry.Journal of Hazardous Materials 2022,423, 127242.

(16) Wu, Z.; Liang, Z.; Guo, S.; Xiao, Y.; Sun, Y.; Qu, L.; Li, Z. Resolving Variable Cell Viability-Induced False Negative: Accurate and High-Contrast Fluorescence Diagnosis of Cancer Enabled by Dual Organelle Targeting and Multiple Microenvironmental Parameters Responsive Versatile Carbon Dots.Sensors and Actuators B: Chemical 2022, 131577.

(17) Yang, R.; Dou, Y.; Zhang, Y.; Qu, L.; Sun, Y.; Li, Z. A Facile and Highly Efficient Fluorescent Turn-on Switch Strategy Based on Diketone Isomerization and Its Application in Peroxynitrite Fluorescent Imaging.Sensors and Actuators B: Chemical 2021,337, 129805.

(18) Hu, J.; Yang, R.; Qin, H.; Sun, Y.; Qu, L.; Li, Z. Spying on the Polarity Dynamics during Wound Healing of Zebrafish by Using Rationally Designed Carbon Dots.Advanced Healthcare Materials 2021, 2002268.

(19) Sun, Y.; Qin, H.; Geng, X.; Yang, R.; Qu, L.; Kani, A. N.; Li, Z. Rational Design of Far-Red to Near-Infrared Emitting Carbon Dots for Ultrafast Lysosomal Polarity Imaging.ACS Appl. Mater. Interfaces 2020,12 (28), 31738–31744.

(20) Wang, J.; Guo, Y.; Geng, X.; Hu, J.; Yan, M.; Sun, Y.; Zhang, K.; Qu, L.; Li, Z. Quantitative Structure–Activity Relationship Enables the Rational Design of Lipid Droplet-Targeting Carbon Dots for Visualizing Bisphenol A-Induced Nonalcoholic Fatty Liver Disease-like Changes.ACS Appl. Mater. Interfaces 2021,13 (37), 44086–44095.