于明明，教授，硕士生导师。

1998年毕业于吉林大学。2005年5月于中科院理化所获博士学位。清华大学化学系博士后工作后，2007年到郑州大学工作。先后被评为校级青年骨干教师、省级青年骨干教师。2017年8月-2018年8月在美国新泽西理工学院进行访学研究。

主要从事生物荧光分子探针和荧光高分子的研究。任职以来主持国家自然科学基金两项，参与多项，在Org. Lett.、Chem. Commun.、Inorg. Chem.、Langmuir、Anal. Chem.、J. Mater. Chem. C等杂志上发表论文四十余篇。2010年9月发表在Chem. Commun.的论文下载次数为当月该杂志的第三。2012年9月发表在New J. Chem.的文章为当月该杂志下载次数Top-Ten的第一。为Biosensors and Bioelectronics、Sensors and Actuators B、Analytica Chimica Acta、Dyes and Pigments等杂志的审稿人，2019年开始为“中国化学快报”青年编委。

联系方式：

电子邮件：yumm@zzu.edu.cn

个人网址：http://www.polymer.cn/ss/yumm/index.html

实验室：物理化学实验楼121

通讯地址：郑州大学化学学院450001

学习经历：

1994.09-1998.07，吉林大学，材料化学，本科

1998.09-2001.07，吉林大学，高分子化学与物理，硕士

2001.07-2005.06，中科院理化所，有机化学，博士

工作经历：

2005.7-2007.06，清华大学化学系，博士后；

2007.9-2011.4，郑州大学化学系，教师；

2011.4-2019.12，郑州大学化学学院，副教授；

2011.9，校级青年骨干教师；

2012.9，省级青年骨干教师；

2016.1-2019.12，郑州大学化学学院，直聘教授；

2017.8-2018.8，美国新泽西理工学院，访问学者。

2019.12至今，郑州大学化学学院，教授

研究方向：

生物荧光分子探针/功能高分子

主持项目：

国家自然科学基金“羧酸酯酶的上转换复合纳米近红外比率发光探针的制备及其生物成像”（项目批准号：U1704161）

郑州大学化学与分子工程学院“青年学术骨干”教师基金

国家自然科学基金“具有双识别协同作用的锌、铜离子荧光分子探针”（项目批准号：50903075）

中国科学院光化学转换与功能材料重点实验室开放课题“人造捕光天线的分子设计与应用”

横向课题“新型显色离子吸附剂的研制”

代表论文：

1.Wang, H.L.; Sun, Y.S.; Lin, X.M.; Feng, W.; Li, Z.X.*; Yu, M.M.* Multi-organelle-targeting pH-dependent NIR fluorescent probe for lysosomal viscosity. Chin. Chem. Lett., 2022, 33, accepted.

2.Wei, W.H.; Liu, W.J; Zhang, H.Y.*; Li, Z.X.*; Yu, M.M.* A novel near-infrared fluorescent probe for the detection of sulfur dioxide derivatives and its application in biological imaging. New J. Chem., 2022, 46, 10746–10751.

3.Zhang, S.; Sun, Y.S.; Liu, W.J; Feng, W.; Zhang, M.*; Li, Z.X.; Yu, M.M.* Coumarin-based fluorescent probes toward viscosity in mitochondrion/lysosome. Anal. Biochem., 2022, 652, 114752.

4.Liu, W.J; Bu, D.D.; Zhang, H.Y.*; Ren, H.H.; Li, Z.X.; Yu, M.M.* A mitochondrial and lysosomal targeted ratiometric probe for detecting intracellular H2S. Anal. Methods, 2022, 14, 101–105.

5.Zhang, Q.; Bu, D.D.; Yu, M.M.*; Zhang, H.Y.*; Li, Z.X.* Synthesis of a NIR fluorescene dye and its application for rapid detection of HSO3−in living cells. Dyes Pigments, 2021, 196, 109753.

6.Lin, X.M.; Liu, W.J.; Xu, S.Y.; Li, Z.X.*; Zhang, H.Y.*; Yu, M.M.* Imaging of intracellular bisulfate based on sensitive ratiometric fluorescent probes. Spectrochim. Acta A, 2022, 265, 120335.

7.Liu, W.J; Yang, C.C.; Zhang, H.Y.*; Li, Z.X.*; Yu, M.M.* Colorimetric and ratiometric fluorescence detection of HSO3−with a NIR fluorescent dye. J. Fluoresc. 2021, 31, 1567–1574.

8.Yang, C.C.; Song, J.S.; Ding, Y.; Ren, H.H.; Yu, M.M.*; Zhang, H.Y.*; Li, Z.X.* Solvent-dependent tautomeric equilibrium between fluorescent colorimetric probes with dual mitochondrial/liposome targetability. Dyes Pigments, 2021, 191, 109377.

9.Bu, D.D.; Wang, Y.Y.; Wu, N.; Feng, W.; Wei, D.H.; Li, Z.X.*; Yu, M.M.* A mitochondrial-targeted ratiometric probe for detecting intracellular H2S with high photostability. Chin. Chem. Lett., 2021, 32, 1799–1802.

10.Zhang, Q.; Song, H.H.; Yu, M.M.*; Zhang, H.Y.*; Li, Z.X.* Preparation of yellow fluorescent N,O-CDs and its application in detection of ClO-. J. Fluoresc. 2021, 31, 659–666.

11.Yang, C.C.; Li, Y.Y.; Wu, N.; Zhang, Y.C.; Feng, W.; Yu, M.M.*; Li, Z.X.* Ratiometric upconversion luminescence nanoprobes for quick sensing of Hg2+ and cells imaging. Sens. Actuators B, 2021, 326, 128841.

12.Hou, Y.; Liu, H.X.; Li, Z.X.*; Zhang, H.Y.*; Wei, L.H.; Yu, M.M.* One-step synthesis of mitochondrion-targeted fluorescent carbon dots and fluorescence detection of silver ions. Anal. Methods, 2020, 12, 2835–2840.

13.Bu, D.D.; Song, H.H.; Li, Z.X.*; Wei, L.H.; Zhang, H.Y.*; Yu, M.M.* Carbon-dot-based ratiometric fluorescent probe of intracellular zinc ion and persulfate ion with low dark toxicity. Luminescence, 2020, 35, 1319–1327.

14.Liu, W.J.; Wang, Y.Y.; Wu, N.; Feng, W.; Li, Z.X.*; Wei, L.H.; Yu, M.M.* A mitochondrion-targeting fluorescent probe for hypochlorite anion in living cells. Spectrochim. Acta A, 2020, 240, 118564.

15.Li, Y.Y.; Ban, Y.N.; Wang, R.H.; Wang, Z.; Li, Z.X.*; Fang, C.J.; Yu, M.M.* FRET-based Ratiometric Fluorescent Detection of Arginine in Mitochondrion with a Hybrid Nanoprobe. Chin. Chem. Lett., 2020, 31, 443–446.

16.Wang, Y.Y.; Liu, H.X.; Song, H.H.; Yu, M.M.*; Wei, L.H.; Li, Z.X.* Synthesis of dual-emission fluorescent carbon quantum dots and their ratiometric fluorescence detection for arginine in 100% water solution. New J. Chem., 2019, 43, 13234−13239.

17.Li, Z.X.; Liu, H.X.; Li, H.X.; Tsou, Y.H.; Gao, Y.L.; Xu, X.Y.*; Du, W.W.; Wei, L.H.; Yu, M.M.* Lysosome-targeting NIR Ratiometric Luminecent Upcoversion Nanoprobe toward Arginine. Sens. Actuators B, 2019, 280, 94–101.

18.Song, H.H.; Du, W.W.; Liu, C.X.; Li, Z.X.*; Zhang, H.Y.*; Wei, L.H.; Yu, M.M.* Self-Assembled Micellar Nanosensor toward pH with high photo-stability and its application in living cells. Sens. Actuators B, 2018, 273, 927–934.

19.Ban, Y.; Wang, R.H.; Li, Y.; An, Z.; Yu, M.M.*; Fang, C.J.*; Wei, L.; Li, Z.X. Mitochondria-targeted ratiometric fluorescent detection of hydrazine with fast response time. New J. Chem., 2018, 42, 2030−2035.

20.Shi, B. J.; He,Y. Y.; Zhang, P. P.; Wang, Y. L.; Yu, M. M.*; Zhang, H. Y.*; Wei, L. H.; Li, Z. X.* Turn on fluorescent detection of hydrazine with a 1,8-naphthalimde derivative. Dyes Pigments, 2017, 147, 152–159.

21.He,Y. Y.; Li, Z. X.*; Jia, Q. Y.; Shi, B. J.; Zhang, H. Y.*; Wei, L. H.; Yu, M. M.* Ratiometric fluorescent detection of acidic pH in lysosome with carbon nanodots. Chin. Chem. Lett., 2017, 28(10), 1969-1974.

22.Li, H. X; Dong, H.; Yu, M. M.; Liu, C. X.; Li, Z. X.; Wei, L. H.; Sun, L. D.; Zhang, H. Y. NIR ratiometric luminescence detection of pH fluctuation in living cells with hemicyanine derivative-assembled upconversion nanophosphors. Anal. Chem., 2017, 89, 8863−8869.

23.Shi, B. J.; Qi, S. J.; Yu, M. M.; Liu, C. X.; Li, Z. X.; Wei, L. H.; Ni, Z. H. Colorimetric and fluorescent detection of hydrazine with high sensitivity and excellent selectivity. Spectrochim. Acta A, 2018, 188, 208–212.

24.He,Y. Y.; Li, Z. X.; Shi, B. J.; An, Z.; Yu, M. M.; Wei, L. H.; Ni, Z. H. A new near-infrared ratiometric fluorescent probe for hydrazine. RSC Adv., 2017, 7, 25634–25639.

25.Yu, M. M.*; Du, W. W.; Li, H. X.; Zhang, H. Y.*; Li, Z. X.* Near-infrared ratiometric fluorescent detection of arginine in lysosome with a new hemicyanine derivative. Biosens. Bioelectron., 2017, 92, 385–389.

26.An, Z.; Li, Z. X.*; He, Y.; Shi, B.; Wei, L.; Yu, M. M.* Ratiometric luminescent detection of hydrazine with a carbon dots-hemicyanine nanohybrid system. RSC Adv., 2017, 7, 10875–10880.

27.Li, Z. X.;* Zhang, W. Y.; Liu, C. X.; Yu, M. M.*; Zhang, H. Y.*; Guo, L.; Wei, L. H. A colorimetric and ratiometric fluorescent probe for hydrazine and its application in living cells with low dark toxicity. Sens. Actuators B, 2017, 241, 665–671.

28.Shi, B. J.; Gao, Y. L.; Liu, C. X.; Feng, W. Li, Z. X.; Wei, L. H.; Yu, M. M.* A ratiometric fluorescent sensor for pH fluctuation and its application in living cells with low dark toxicity. Dyes Pigments, 2017, 136, 522–528.

29.Li, Z. X.; Li, H. X.; Shi, C. X.; Yu, M. M.; Wei, L. H.; Ni Z. H. Nanomolar colorimetric quantitative detection of Fe3+ and PPi with high selectivity. Spectrochim. Acta A, 2016, 159, 249–253.

30.Yu, M. M.*, Du, W. W.; Zhou, W.; Li, H. X.; Liu, C. X.; Wei, L. H.; Li, Z. X.*; Zhang, H. Y. A 1,8-naphthalimide-based chemosensor with an off-on fluorescence and lifetime imaging response for intracellular Cr3+ and further for S2−. Dyes Pigments, 2016, 126, 279–285.

31.Li, Z. X.*; Li, H. X.; Shi, C. X.; Zhang, W. Y.; Zhou, W.; Wei, L. H.; Yu, M. M.* Naked-eye-based highly selective sensing of Fe3+ and further for PPi with nano copolymer Film. Sens. Actuators B, 2016, 226, 127–134.

32.Yu, M. M.*; Xu, J.; Peng, C.; Li, Z. X.; Liu, C. X.; Wei, L. H. A novel colorimetric and fluorescent probe for detecting fluoride anions: from water and toothpaste samples. Tetrahedron, 2016, 72, 273–278.

33.Xu, L. J.; Liang, X. Y.; Zhang, L.; Wu, J. B.; Li, Z. X.; Yu, M. M.*; Wei, L. H.* The vesicle formation ofβ-CD and AD self-assembly of dumbbell-shaped amphiphilic triblock copolymer. Colloid Polym. Sci., 2016, 294, 145–155.

34.Zhang, W. Y.; Liu, X. J.; Zhang, H. Y.; Feng, C. C.; Liu, C. X.; Yu, M. M.*; Wei, L. H.; Li, Z. X.* A fluorescent probe for benzenethiols and its application on test paper, in water samples and living cells. J. Mater. Chem. C, 2015, 3, 8248–8254.

35.Liu, C. X.; Shi, C. X.; Li, H. X.; Du, W. W.; Li, Z. X.*; Wei, L. H.; Yu, M. M.* Nanomolar fluorescent quantitative detection of formaldehyde with a 8-hydroxyquinoline derivative in aqueous solution and electrospun nanofibers. Sens. Actuators B, 2015, 219, 185–191.

36.Li, Z. X.*; Zhang, W. Y.; Liu, X. J.; Liu, C. X.; Yu, M. M.*; Wei, L. H.* Naked-eye-based selective detection of pyrophosphate with Zn2+ complex in aqueous solution and electrospun nanofibers. RSC Adv., 2015, 5, 25229–25235.

37.Liu, C. X.; Xu, J.; Yang, F.; Zhou, W.; Li, Z. X.*; Wei, L. H.; Yu, M. M.* Nanomolar Cu2+ and F–naked-eye detection with a 1,8-naphthalimide-based colorimetric probe. Sens. Actuators B, 2015, 212, 364–370.

38.Du, W. W.; Xu, J.; Li, H. X.; Feng, C. C.; Yu, M. M.*; Li Z. X.;* Wei L. H. Naked-eye and fluorescent detection of basic pH and F−with a 1,8-naphthalimide-based multifunctional probe. RSC Adv., 2015, 5, 15077–15083.

39.Zhou, W.; Dong, H.; Yan, H.; Shi, C. X.; Yu, M. M.*; Wei, L. H.; Li, Z. X.* HCHO-reactive molecule with dual-emission-enhancement property for quantitatively detecting HCHO in near 100% water solution. Sens. Actuators B, 2015, 209, 664–669.

40.Liu, X. J.; Zhang, W.Y.; Li, C. X.; Zhou, W.; Li, Z. X.*; Yu, M. M.*; Wei, L. H. Nanomolar detection of Hcy, GSH and Cys in aqueous solution, test paper and living cells. RSC Adv., 2015, 5, 4941–4946.

授权专利：

·于明明、卜丹丹、李占先、刘含笑、魏柳荷，一种线粒体定位的碳点、制备方法及其在银离子检测中的应用。2019.10.12，中国，专利号：ZL201910969065.X

·于明明、李占先、杜玮玮、李海霞、魏柳荷，一种溶酶体定位荧光探针在近红外比率检测肼中的应用。2016.10.20，中国，专利号：ZL201610923191.8

·于明明、施冰杰、刘春霞、李占先、魏柳荷，一种线粒体靶向的pH敏感的比率型荧光探针及其制备方法和应用。2016.07.06，中国，专利号：ZL201610221971.8

·于明明、张文英、李占先、石彩霞、周婉、魏柳荷，一种高分子比色纳米薄膜材料及其制备方法以及用于Fe3+和焦磷酸根检测方面的应用。2015.05.26，中国，专利号：ZL201510292665.9

·于明明、李海霞、严晗、周婉、李占先、魏柳荷，一种甲醛快速检测试剂及其制备方法与应用。2016.11.02，中国，专利号：ZL201410500026.2

·于明明、张文英、刘兴江、周婉、李占先、魏柳荷，一种检测焦磷酸根的纳米纤维膜试条、制备方法及其应用。2015.11，中国，专利号：ZL201410402826.0

·于明明、李占先、魏柳荷、刘兴江，一种氟硼荧光衍生物、其制备方法及应用。2015.11，中国，专利号：ZL201310171197.0

·于明明、乔钰茜、李占先、魏柳荷、郭永开，2,4-二苯基-5,6-二吡啶基-苯酚及其制备。2015.6，中国，专利号：ZL201310518992.2

·于明明、李占先、魏柳荷、张利锋、赵万莹、王丽娜，苯衍生物金属离子荧光探针及其应用。2014.4，中国，专利号：ZL201110169893.9