一、个人简介

钱永常，博士，男，出生于1962年2月，浙江农林大学特聘教授，浙江农林大学校学术委员会委员，美国Texas A&M大学兼职副教授，浙江省“千人计划” 特聘专家，国家林业局铁皮石斛工程技术研发中心副主任，浙江省生物工程学会理事、省毒理学学会理事、省药学会生化药物专业委员会理。

二、研究方向

中药资源功效成分；神经细胞功能恢复；细胞水平血糖控制；细胞水平免疫调控

三、工作经历

1991.4-1993.7 美国加州大学戴维斯分校（UC-Davis），植物生理与生化博士后

1993.8-1997.10，美国德州农工大学（Texas A&M），生化与分子生物学博士后

1997.11-1999.10，美国德州农工大学（Texas A&M），生物医学研究员

1999.11-2012.1，美国德州农工大学（Texas A&M），助理教授、副教授

2012.2-至今，美国德州农工大学（Texas A&M），兼职副教授

2012.4-至今，浙江农林大学，特聘教授

四、学术及科研项目、成果情况

1、承担教学工作

本科生：Developmental Neurotoxicology；生物制剂与生物检测；化学生物学导论

研究生：Chemical Hazard Assessment；Neuroanatomical Systems: Neurodegenerative Diseases；Neurobiology；化学生物学

2、科研项目

（1）美国德州A&M大学CVM优先计划,  "Lead and Copper Competitively Bind to HMB of ATP7A and GRP78" (项目主任, 25%贡献)

（2）美国国立环境与健康研究所项目NIEHS P42 ES04917, “Stress Gene Induction in Mammalian Cells” (项目副主任, 40%贡献)

（3）美国国防部项目DOD-CDMRP Concept Award W81XWH-05-1-0163,  "The Function of Neurofibromin in Astrocytes" (项目副主任, 40%贡献)

（4）美国德州A&M大学基金, “The Function of Astrocytes in Brain Glucose Utilization” (项目主任, 50% 贡献)

（5）美国国立环境与健康研究所项目NIH-NIEHS R21, “Long-Term Monitoring of Dementia-Related Markers in Lead Workers from China” (项目主任, 30% 贡献)

（6）浙江农林大学科研发展基金RF2012017，“天然产物功能因子筛选平台的建立”（项目主任，50%贡献）

（7）浙江省林业厅省院合作林业科技项目2015SY04，“山核桃神经功能因子挖掘与产品开发的研究”（项目主任，50%贡献）

3、发表的主要论文

1. Fei Gao, Xiangjun Wang, Aicun Zhou, Evelyn Tiffany-Castiglioni, Lijun Xie,Yongchang Qian(钱永常)* Cellular Evaluation of Anti-tumor Components from Toad Venom.Oncology Letters, in press, 2016

2. Fei Gao, W.F. Xu, Lingping Tang, Mengmeng Wang, Xiangjun Wang,Yongchang Qian(钱永常)*. Characteristic of cathelicidin-Bg, a novel gene expressed in ear-side gland of Bufo gargarizans.Genetics and Molecular Research, in press,2016.

3. 高  飞，李彤彤，汤玲平，王向军，林莉燕，钱永常*。基于DNA条形码的龙葵系统发育及变异为点分析。中草药，47(1): 114-121, 2016 (abstract in English).

4. 李彤彤，高    飞，段承俐，王向军，钱永常*。滇重楼中VEGF结合因子的活性研究。中草药, 46(15): 2251-2256，2015(abstract in English).

5. 高   飞，周   瑜，王向军，李彤彤，张   宇，黄瑜秋，钱永常*。竹叶提取物抗肿瘤和神经保护作用研究。中草药，46(5): 710-715, 2015(abstract in English).

6. 周   瑜，黄坚钦，高   飞，王向军，钱永常*。交联聚乙烯吡咯烷酮（PVPP）对山核桃中多酚去除效果的毒理学评价。食品工业科技, 36(6): 104-108, 2015(abstract in English).

7. Wang Xiang-jun, Wu Huai-xiu, Ye Shan-shan, Pan Lan-ying,Qian Yongchang (钱永常)*Expression of recombinant human acetylcholinesterase and its application in screening inhibitors.Acta Pharmaceutica Sinica, 49 (1): 50-54,2014

8. Yongchang Qian (钱永常)*, Bingchao Meng, Xuchu Zhang, Ying Zheng, Robert Taylor, Evelyn Tiffany-Castiglioni. HSPA5 Forms Specific Complexes with Copper.Neurochemical Research38: 321-329,2013. 

9. Tiffany-Castiglioni, E.,Qian, Yongchang (钱永常). ER Chaperone-Metal Interactions:  Links to Protein Folding Disorders.Neurotoxicology 33: 545-557,2012. (7)

10. Qian, Yongchang (钱永常)*, Zheng, Y., Taylor, R., Tiffany-Castiglioni, E. Involvement of the Molecular Chaperone HSPA5 in Copper Homeostasis in Astrocytes.Brain Research 1447: 9-19,2012. (11)

11. Tiffany-Castiglioni, E., Hong, S.,Qian, Yongchang (钱永常). Copper Handling by Astrocytes:  Insights into Neurodegenerative Diseases.International Journal of Developmental Neuroscience 29: 811-818,2011. (28)

12. Tiffany-Castiglioni, E.,Qian, Yongchang (钱永常), Barhoumi, R., Zheng, Y. Determination of Metal Interactions with the Chaperone Hspa5 in Human Astrocytoma Cells and Rat Astrocyte Primary Cultures.Methods in Molecular Biology, 758: 29-48,2011.

13. Barhoumi, R.,Qian, Yongchang (钱永常), Burghardt, R., Tiffany-Castiglioni, E. Image Analysis of Ca2+ Signals as a Basis for Neurotoxicity Assays:  Promises and Challenges.Neurotoxicology and Teratology. 32: 16-24,2010. (11)

14. Qian, Yongchang (钱永常)*, Zheng, Y, Tiffany-Castiglioni, E. Valproate Reversibly Reduces Neurite Outgrowth by Human SY5Y Neuroblastoma Cells.Brain Research 1302:21-33,2009. (9)

15. Wang, LJ, Zheng, Y,钱永常*.断乳仔鼠器官中铅分布和78000糖调蛋白的变化. 《中华预防医学杂志》第42卷，第10期：731-734页,2008 (abstract in English).

16. White, LD., Cory-Slechta, DA., Gilbert, ME., Tiffany-Castiglioni, E., Zawia, NH., Virgolini, M., Rossi-George, A., Lasley, SM.,Qian, Yongchang (钱永常), Basha, MR. New and Evolving Concepts in the Neurotoxicology of Lead.Toxicology and Applied Pharmacology 225: 1-27,2007. (192)

17. Qian, Yongchang (钱永常)*,Zheng, Y, Weber, D, Tiffany-Castiglioni, E. A 78kD Glucose-Regulated Protein Is Involved In Decrease Of Interleukin-6 Secretion By Lead Treatment From Astrocytes.American Journal of Physiology-Cell Physiology 293: C897-C905,2007. (16)

18. Wang, L. J., Zheng, Y.,钱永常*.低水平铅暴露对仔鼠白细胞78kd糖调蛋白表达的影响. 《国际医药卫生导报》第13卷，第12期：8-12页，2007 (abstract in English).

19. Falahatpisheh, H., Nanez, A., Montoya-Durago, D., Qian, Yongchang (钱永常), Tiffany-Castiglioni, E., Ramos, KS. Activation Profiles of HSPA5 During the Glomerular Mesangial Cell Stress Response to Chemical Injury.Cell Stress & Chaperones 12: 209-218,2007. (13)

20. Barhoumi, R., Burghardt, R.,Qian, Yongchang (钱永常), Tiffany-Castiglioni, E. Effects of propofol on intracellular Ca2+ homeostasis in human astrocytoma cells.Brain Research 1145: 11-18,2007. (19)

21. Qian, Yongchang (钱永常), Venkatraj, J., Barhoumi, R., Pal, R., Datta, A., Wild, J. R., Tiffany-Castiglioni, E. Comparative non-cholinergic neurotoxic effects of paraoxon and diisopropyl fluorophosphate (DFP) human neuroblastoma and astrocytoma cell lines.Toxicology and Applied Pharmacology 219: 162-171,2007. (16)

22. Tiffany-Castiglioni, E., Hong, S.,Qian, Yongchang (钱永常), Tang, Y., Donnelly, K.C.  COMMENTARY:  In Vitro Models for Assessing Neurotoxicity of Mixtures.Neurotoxicology 27: 835-839,2006. (20)

23. Tiffany-Castiglioni, E., Venkatraj, J.S.,Qian, Yongchang (钱永常).  Genetic polymorphisms and mechanisms of neurotoxicity:  overview.  Neurotoxicology 26: 641-649,2005.

24. Qian, Yongchang (钱永常)*, Zheng, Y., Ramos, K.S., Tiffany-Castiglioni, E. The Involvement of Copper Transporter in Lead-induced Oxidative Stress in Astroglia.Neurochemical Research 30: 429-438,2005. (27)

25. Qian, Yongchang (钱永常)*, Zheng, Y., Abraham, L., Ramos, K.S., Tiffany-Castiglioni, E. Differential Profiles of Copper-induced ROS Generation in Human Neuroblastoma and Astrocytoma Cells.Molecular Brain Research 134: 323-332,2005. (30)

26. Qian, Yongchang (钱永常)*, Zheng, Y., Ramos, K.S., Tiffany-Castiglioni, E. GRP78 compartmentalized redistribution in pb-treated glia: role of grp78 in lead-induced oxidative stress.Neurotoxicology 26: 267-275,2005. (45)

4、出版专著

1. Yongchang Qian(钱永常)*,Evelyn Tiffany-Castiglioni. Lead-Induced Developmental Neurotoxicity and Modulated Gene Expression. In:Comprehensive Toxicology, Third Edition. Charlene A. McQueen (ed.). Elsevier,2016, pp. xxx.

2. Yongchang Qian(钱永常)*, Linjing Wang, Evelyn Tiffany-Castiglioni. Lead-Modulated Gene Expression in the Central Nervous System. In:Reference Module in Biomedical Sciences Reviews. Michael Caplan (ed). Elsevier, 2014, pp. 29

3. Qian, Yongchang (钱永常). Heavy Metal-Regulated Gene Expression in the Nervous System. In:Comprehensive Toxicology, Second Edition. Kenneth S. Ramos (ed.). Elsevier, Oxford,2010, pp. 495-521.

4. Tiffany-Castiglioni, E., Venkatraj, J.S.,Qian, Yongchang (钱永常),Wild, J.R.   Chapter 22 In vitro models for testing organophosphate-induced neurotoxicity and remediation.  In:  Toxicology of Organophosphate & Carbamate Pesticides, Ramesh C. Gupta (ed).  Elsevier, Amsterdam,2006, pp. 315-337.

5. Tiffany-Castiglioni, E.,Qian, Yongchang (钱永常). Chapter 26 Astroglia and Lead Neurotoxicity. In:The Role of Glia in Neurotoxicity, Second Edition. M. Aschner, L. G. Costa (eds), CRC Press, Boca Raton, FL,2005, pp. 417-437.

6. Tiffany-Castiglioni, E.,Qian, Yongchang (钱永常). Cell-Type Specific Responses of the Nervous System to Lead. In:Methods in Pharmacology and Toxicology: In Vitro Neurotoxicology: Principles and Challenges. E. Tiffany-Castiglioni (ed), Humana Press Inc., Totowa, NJ,2004, pp.151-186

7. Harris, E. D., Reddy, M. C. M.,Qian, Yongchang (钱永常), Tiffany-Castiglioni, E., Majumdar, S., Nelson, J. Multiple forms of the Menkes Cu-ATPase. In: Leone, A., Mercer, J. F. B. (Ed.), Copper Transport and Its Disorders. Kluwer Academic/ Plenum Publishers, New York,1999, pp. 39-51.

8. Harris, E.D., Tiffany-Castiglioni, E.,Qian, Yongchang (钱永常).  Copper in cell culture.  In: Trace Element in Laboratory Rodents: Nutritional Research Methods, R.R. Watson (ed), CRC Publishers, Boca Raton, FL,1996, pp.163-187

5、获奖情况

（1）美国毒理学会Gulf Coast分会优秀博士后奖

（2）浙江省“千人计划”创业人才

（3）浙江省杭州市萧山区“优秀留学人员创业人才”

（4）浙江省杭州市萧山区“十佳优秀科技人才”

（5）浙江省杭州市萧山区首届“爱乡名士”

五、联系方式

联系地址：浙江农林大学林业与生物技术学院，浙江杭州临安，311300

电　　话：15988453541

电子邮件：qian3906@zafu.edu.cn