梁尚栋 博士

南昌大学基础医学院教授（二级教授），博士生导师、硕士生导师。

国务院特殊津贴和江西省政府特殊津贴获得者、江西省“赣鄱英才 555 工程”人选专家、江西省百千百万人才一、二层次人选、江西省教学名师奖获得者。

国际脑研究组织会员、中国神经科学会理事、江西省生理科学会理事长、江西省神经科学学会副理事长。

Autonomic Neuroscience: Basic and Clinical(SCI 收录), Neurochemistry International(SCI 收录), Brain Res Bull(SCI 收录)杂志编委。

Pain、Molecular Neurobiology、British Journal of Pharmacology、Neuropharmacology、Journal of Cellular Physiology、ACS Chemical Neuroscience、Journal of Biomedicine & Pharmacotherapy、Current Medicinal Chemistry、PLose one、Purinergic Signaling、Advances in Pharmacology等国际杂志审稿专家。

华中科技大学同济医学院博士毕业。曾获国际脑研究组织（IBRO）资助，赴匈牙利科学院实验医学研究所神经药理系研究学习二年。另申请到英国威康研究基金（Wellcome Trust）的科研课题资助，在英国伦敦大学学院自主神经科学研究所开展过研究工作。2009年赴美国内布拉斯加大学医学院药理和实验神经科学系进行工作访问，并被聘为内布拉斯加大学医学院药理和实验神经科学系客座教授（Visiting Professor）。

l 研究兴趣、领域：

课题组致力于多年来一直从事外周神经节的生理、病理生理与药理学研究工作。主要从事神经病理痛外周神经损伤、心肌缺血与外周神经节病理生理、糖尿病并发外周神经损伤、糖尿病血管内皮损伤等研究。

现主持三项国家自然科学基金课题《长非编码RNA-US在颈部交感神经节P2X4受体介导糖尿病心交感神经病理损伤中的作用及机制研究；主持，项目批准号：81870574（面上项目）》、《背根神经节神经元与卫星胶质细胞间作用涉及探究糖尿病神经病理痛机制和潜在治疗靶点的新途径；主持，项目批准号：81570735（面上项目）》和《背根神经节嘌呤2X受体介导HIV及其治疗相关神经病理痛的作用机制和拮抗研究；主持，项目批准号：31560276（地区项目）》。

主持完成国家自然科学基金课题六项《川芎嗪对P2X3受体介导的伤害性感受的作用及机理研究；主持，批准号：30260030》、《P2X3受体在颈部交感神经节细胞介导心肌痛伤害性信息传递的作用研究；主持，批准号：30460040》、《P2X2/3受体在结状神经节细胞介导心肌痛伤害性信息传递的作用研究；主持，批准号：30660048》、《初级感觉神经元血管内皮生长因子及其受体在神经病理痛中的作用及机理研究；主持，批准号：30860086》、《颈部交感神经节P2X7受体与心肌缺血损伤介导失稳态交感反射的研究；主持，批准号：31060139》和《自主和初级感觉神经节中与糖尿病神经病变相关的类似mRNA的非编码RNA作用研究；主持，项目批准号：81171184》；主持完成一项教育部高等学校博士点专项科研基金课题《葛根素对初级感觉神经元P2X3受体介导烧伤痛的作用研究（批准号：20070403007）》。

发表研究论文130多篇（其中SCI收录杂志70余篇）。获江西省自然科学二等奖一项、江西省自然科学三等奖二项（均为第一完成人）。获批美国发明专利一项、中国知识产权局发明专利二项（均为第一完成人）。

l 近三年在SCI收录杂志发表的论文：

Xu H, Xiong C, He L, Wu B, Peng L, Cheng Y, Jiang F, Tan L, Tang L, Tu Y, Yang Y, Liu C, Gao Y, Li G, Zhang C, Liu S, Xu C, Wu H, Li G, Liang S(梁尚栋)*. Trans-Resveratrol Attenuates High Fatty Acid-Induced P2X7 Receptor Expression and IL-6 Release in PC12 Cells: Possible Role of P38 MAPK Pathway. Inflammation. 2015, 38(1):327-37.

Liu SM, Shi QM, Zhu QC, Zou T, Li GL, Huang A, Wu B, Peng LC, Song MM, Wu Q,  Xie QY, Lin WJ, Xie W, Wen SY, Zhang ZD, Lv QL, Zou LF, Zhang X, Ying MF, Li GD, Liang SD(梁尚栋)*. P2X7 receptor of rat dorsal root ganglia is involved in the effect of moxibustion on visceral hyperalgesia. Purinergic Signalling, 2015,11( 2): 161-169.

Gao Y, Zhang J, Li GL, Xu H, Yi Y, Wu Q, Song MM, Bee YM, Huang LP, Tan MG, Liang SD(梁尚栋), Li GD. Protection of vascular endothelial cells from high glucose-induced cytotoxicity by emodin. Biochemical Pharmacology, 2015, 94(1): 39-45.

Zhang J, Liu SM, Xu BH, Li GD, Li GL, Wu B, Peng LC, Song MM, Wu Q, Xie QY, Lin WJ, Xie W, Wen SY, Zhang ZD, Xu XL, Lv QL, Zou LF, Zhang X, Ying MF, Liang SD(梁尚栋)*. Study of baicalin on sympathoexcitatory activity induced by myocardial ischemia via P2X3 receptor in rat superior cervical ganglia. Autonomic Neuroscience: Basic and Clinical, 2015, 189:8-15.

Xiong W, Qiu SY, Xu LY, Zhang CP, Yi Y, Wu Q, Huang LP, Liu SM, Wu B, Peng LC, Song MM, Gao Y, Liang SD(梁尚栋)*. Effect of intermedin in dorsal root ganglia on the transmission of neuropathic pain of CCI rats. Clinical and Experimental Pharmacology and Physiology, 2015, 42(7): 780–787.

Wu H, Nie YY, Xiong HG, Liu SM, Li GL, Huang A, Guo LL, Wu B, Peng LC, Song MM, Li GD, Liang SD(梁尚栋)*. P2X7 receptor expression in peripheral blood monocytes is correlated with plasma C reactive protein and cytokine levels in patients with type 2 diabetes mellitus: a preliminary report. Inflammation, 2015, 38(6): 2076-2081.

Lv QL, Xue Y, Li GD, Zou LF, Zhang X, Ying MF, Wang SY, Guo LL, Gao Y, Li GL, Xu H, Liu SM, Xie JY, Liang SD(梁尚栋)*. Beneficial effects of evodiamine on P2X4-mediated inflammatory injury of human umbilical vein endothelial cells due to high glucose. International Immunopharmacology, 2015, 28: 1044–1049.

Lv QL, Wang K, Xu DZ, Liu MY, Wan Q, Huang HY, Liang SD(梁尚栋), Zhang XY(张小勇), Wei Y. Synthesis of amphiphilic hyperbranched AIE-active fluorescent organic nanoparticles and their application in biological application. Macromolecular Bioscience, 2016, 16 (2): 223-230. DOI:10.1002/mabi.201500256

Zou LF, Tu GH, Xie W, Wen SY, Xie QY, Liu SM, Li GL, Gao Y, Xu H, Wang SY, Xue Y, Wu B, Lv QL, Ying MF, Zhang X,Liang SD(梁尚栋)*. The long noncoding RNA NONRATT021972 is involved in the pathophysiologic processes mediated by P2X7 receptors in stellate ganglia after myocardial ischemic injury. Purinergic Signalling, 2016, 12(1): 127-137.

Wang SY, Xu H, Zou LF, Xie JY, Wu H, Wu B, Yi ZH, Lv QL, Zhang X, Ying MF, Liu SM, Li GL, Gao Y, Xu CS, Zhang CP, Xue Y, Liang SD(梁尚栋)*. LncRNA uc.48+ is involved in diabetic neuropathic pain mediated by the P2X3 receptor in the dorsal root ganglia. Purinergic Signalling, 2016, 12:139-148.

Wu B, Zhang CP, Zou LF, Ma YC, Huang KY, Lv QL, Zhang X, Wang SY, Xue Y, Yi ZH, Jia TY, Zhao SH, Liu SM, Xu H, Li GL, Liang SD(梁尚栋)*. LncRNA uc.48+ siRNA improved diabetic sympathetic neuropathy in type 2 diabetic rats mediated by P2X7 receptor in SCG. Autonomic Neuroscience: Basic and Clinical, 2016,197: 14–18.

Li GL, Zou LF, Xie W, Wen SY, Xie QY, Gao Y, Xu CS, Xu H, Liu, SM, Wang SY, Xue Y, Wu B, Lv QL, Ying MF, Zhang X, Liang SD(梁尚栋)*. The effects of NONRATT021972 lncRNA siRNA on PC12 neuronal injury mediated by P2X7 receptor after exposure to oxygen-glucose deprivation. Purinergic Signalling, 2016, 12 (3):479-87. DOI:10.1007/s11302-016-9513-8(出版年:2016-Sep (Epub  Apr 21))

Liu SM, Zou LF, Xie JJ, Xie W, Wen SY, Xie QY, Gao Y, Li GL, Zhang CP, Xu CS, Xu H, Wu B, Lv QL, Zhang X, Wang SY, Xue Y, Liang SD(梁尚栋)*. LncRNA NONRATT021972 siRNA regulates neuropathic pain behaviors in type 2 diabetic rats through the P2X7 receptor in dorsal root ganglia. Mol Brain. 2016; 9: 44. Published online 2016 April 23. doi: 10.1186/s13041-016-0226-2

Tu GH, Zou LF, Liu SM, Wu B, Lv QL, Wang SY, Xue Y, Zhang CP, Yi ZH, Zhang X, Li GL, Liang SD(梁尚栋)*. Long noncoding NONRATT021972 siRNA normalized abnormal sympathetic activity mediated by the upregulation of P2X7 receptor in superior cervical ganglia after myocardial ischemia. Purinergic Signalling, 2016, 12: 521–535.

Lv QL, Wang K, Xu DZ, Liu MY, Wan Q, Huang HY, Liang SD(梁尚栋), Zhang XY, Wei Y. Facile preparation and biological imaging of luminescent polymeric nanoprobes with aggregation-induced emission characteristics through Michael addition reaction. Colloids and Surfaces B: Biointerfaces, 2016, 145: 795–801.

Xu H, He LL, Liu CL, Tang L, Xu YH, Xiong MQ, Yang M, Fan YF, Hu FF, Liu XZ, Ding L, Gao Y, Xu CS, Li GL, Liu SM, Wu B, Zou LF, Liang SD(梁尚栋)*. LncRNA NONRATT021972 siRNA attenuates P2X7 receptor expression and inflammatory cytokine production induced by combined high glucose and free fatty acids in PC12 cells. Purinergic Signalling, 2016,12(2): 259–268. Published online 2016 Feb 10. doi: 10.1007/s11302-016-9500-0

Wu H, Li GD, Nie YJ, Zou LF, Zhang X, Liu SM, Li GL, Xu H, Zhang CP, Liang SD(梁尚栋)*. Potential involvement of P2 receptors in the pathological processes of hyperthyroidism: a pilot study. Annals of Clinical and Laboratory Science, 2016, 46(3): 254-259.

Chen Q, Hu J, Qin SS, Liu CL, Wu H, Wang JR, Lu XM, Wang J, Chen GQ, Liu Y, Liu BY, Xu CS, Liang, S(梁尚栋). Protective effects of naringin against gp120-induced injury mediated by P2X7 receptors in BV2 microglial cells. Genetics and Molecular Research, 2016, 15(2): DOI:10.4238/gmr.15028649

Xu H, Liu CL, Rao SQ, He LL, Zhang TL, Sun SS, Wu B, Zou LF, Wang SY, Xue Y, Jia TY, Zhao SH, Li GL, Liu SM, Li GD, Liang SD(梁尚栋)*. LncRNA NONRATT021972 siRNA rescued decreased heart rate variability in diabetic rats in superior cervical ganglia. Autonomic Neuroscience: Basic and Clinical, 2016,201: 1–7.

Wang J, Liu SM, Nie YJ, Wu B, Wu Q, Song MM, Tang M, Xiao L, Xu P, Tan XM, Zhang LY, Li G, Liang SD, Zhang CP. Activation of P2X7 receptors decreases the proliferation of murine luteal cells. Reproduction, Fertility, and Development, 2015, 27(8):1262-1271. DOI: 10.1071/RD14381

Liu H, Liu JN, Xu EQ, Tu GH, Guo ML, Liang SD(梁尚栋), Xiong HG. Human immunodeficiency virus protein Tat induces oligodendrocyte injury by enhancing outward K+ current conducted by KV1.3. Neurobiology of Disease, 2017, 97(Part A): 1-10.

Peng HY, Zou LF, Xie JY, Wu H, Wu B, Zhu GC, Lv QL, Zhang X, Liu SM, Li GL, Xu H, Gao Y, Xu CS, Zhang CP, Wang SY, Xue Y, Liang SD(梁尚栋)*. LncRNA NONRATT021972 siRNA decreases diabetic neuropathic pain mediated by the P2X3 receptor in dorsal root ganglia. Molecular Neurobiology, 2017, 54:511–523.

Li GL, Sheng X, Xu YR, Jiang HD, Zheng CR, Guo JJ, Sun SS, Yi ZH, Qin SL, Liu SM, Gao Y, Zhang CP, Xu H, Wu B, Zou LF, Liang SD(梁尚栋)*, Zhu GC. Co-expression changes of lncRNAs and mRNAs in the cervical sympathetic ganglia in diabetic cardiac autonomic neuropathic rats. Journal of Neuroscience Research, 2017, 95:1690–1699.

Rao SQ, Liu SM, Zou LF, Jia TY, Zhao SH, Wu B, Yi ZH, Wang SY, Xue Y, Gao Y, Xu CS, Li GL, Xu H, Zhang CP, Liang SD(梁尚栋)*. The effect of sinomenine in diabetic neuropathic pain mediated by the P2X3 receptor in dorsal root ganglia. Purinergic Signalling, 2017, 13(2): 227–235. (Erratum: Purinergic Signalling (2017) 13:237).

Xie JY, Liu SM, Wu B, Li GL, Rao SQ, Zou LF, Yi ZH, Zhang CP, Jia TY, Zhao SH, Schmalzing G, Hausmann R, Nie H, Li GD, Liang SD(梁尚栋)*. The protective effect of resveratrol in the transmission of neuropathic pain mediated by the P2X7 receptor in the dorsal root ganglia. Neurochemistry International, 2017, 103: 24-35.

Yi ZH, Rao SQ, Ouyang SA, Bai Y, Wu B, Zou LF, Wang SY, Xue Y, Jia TY, Zhao SH, Gao Y, Liu SM, Xu H, Zhang CP, Liang SD(梁尚栋)*, Guilin Li. A317491 relieved HIV gp120-associated neuropathic pain involved in P2X3 receptor in dorsal root ganglia. Brain Research Bulletin, 2017, 130: 81–89.

Ying M, Liu H, Zhang T, Jiang C, Gong Y, Wu B, Zou L, Yi Z, Rao S, Li G, Zhang C, Jia T,  Zhao S, Yua H, Shi L, Li L, Liang S(梁尚栋)*, Liu S. Effect of artemisinin on neuropathic pain mediated by P2X4 receptor in dorsal root ganglia. Neurochemistry International, 2017, 108 :27-33.

Song MM, Zou LF, Peng LC, Liu SM, Wu B, Yi ZH, Gao Y, Zhang CP, Xu H, Xu YR, Tang MX, Wang SY, Xue Y, Jia TY, Zhao SH, Liang SD(梁尚栋)*, Li GL. LncRNA NONRATT021972 siRNA normalized the dysfunction of hepatic glucokinase through AKT signaling in T2DM rats. Endocrine Research, 2017, 42(3):180-190.

Wu B, Ma YC, Yi ZH, Liu SM, Rao SQ, Zou LF, Wang SY, Xue Y, Jia TY, Zhao SH, Shi LR, Lin Li, Yuan HL, Liang SD(梁尚栋)*. Resveratrol-decreased hyperalgesia mediated by the P2X7 receptor in gp120-treated rats. Molecular Pain, 2017, 13: 1–9.

Xu H, Gong CX, He LL, Rao SQ, Liu XZ, Nie YJ, Liu CL, Li T, Ding L, Tu YM, Yang YP, Hu FF, Fan YF, Wang H, Wang S, Xiong CP, Zhong PP, Tang L, Liang SD(梁尚栋)*. Purinergic P2X7 receptor functional genetic polymorphisms are associated with the susceptibility to osteoporosis in Chinese postmenopausal women. Purinergic Signalling, 2017, May 11. doi: 10.1007/s11302-017-9566-3. [Epub ahead of print].

Xiong W, Tan M, He L, Ou X, Jin Y, Yang G, Huang L, Shen Y, Guan S, Xu C, Li G, Liu S, Xu H, Liang S(梁尚栋)*, Gao Y. Inhibitory effects of tetramethylpyrazine on pain transmission of trigeminal neuralgia in CCI-ION rats. Brain Res Bull., 2017, 134:72-78.

Li G, Jiang H, Zheng C, Zhu G, Xu Y, Sheng X, Wu B, Guo J, Zhu S, Zhan Y, Lin W, Ding R, Zhang C, Liu S, Zou L, Yi Z, Liang S(梁尚栋)*. Long noncoding RNA MRAK009713 is a novel regulator of neuropathic pain in rats. Pain. 2017 Oct;158(10):2042-2052.

Li L, Sheng X, Zhao SH, Zou LF, Han XY, Gong YX, Yuan HL, Shi LR, Guo LL, Jia TY, Liu SM, Wu B, Yi ZH, Liu H, Gao Y, Li GL, Li GD, Zhang CP, Xu H, Liang SD(梁尚栋)*. Nanoparticle-encapsulated emodin decreases diabetic neuropathic pain probably via a mechanism involving P2X3 receptor in the dorsal root ganglia. Purinergic Signalling, 2017, 13:559–568.

Shi LR, Wu B, Yi ZH, Zhao SH, Zou LF, Li L, Yuan HL, Jia TY, Liu SM, Liu H, Gao Y, Li GL, Xu H, Zhang CP, Liang SD(梁尚栋)*. P2Y12 shRNA treatment relieved HIV gp120-induced neuropathic pain in rats. Neurochemistry International, 2018, 112: 259-266.

Zhao S, Yang J, Han X, Gong Y, Rao S, Wu B, Yi Z, Zou L, Jia T, Li L, Yuan H, Shi L, Zhang C, Gao Y, Li G, Liu S, Xu H, Liu H, Liang S(梁尚栋)*. Effects of nanoparticle-encapsulated curcumin on HIV-gp120-associated neuropathic pain induced by the P2X3 receptor in dorsal root ganglia. Brain Res Bull. 2017 Oct;135:53-61.

Wu B , Peng L , Xie J , Zou L , Zhu Q , Jiang H , Yi Z , Wang S , Xue Y , Gao Y , Li G , Liu S , Zhang C , Li G , Liang S(梁尚栋)* , Xiong H . The P2X7 receptor in dorsal root ganglia involved in HIV gp120-associated neuropathic pain. Brain Res Bull. 2017 Oct;135:25-32.

Zou LF, Gong YX, Zhao SH, Yi ZH, Han XY, Wu B, Jia TY, Li L, Yua HL, Shi LR, Zhang CP, Gao Y, Li GL, Xu H, Liu H, Liang SD (梁尚栋)*, Liu SM. Downregulation of P2Y12 in the superior cervical ganglia alleviates abnormal sympathetic activity after myocardial ischemia. Journal of Cellular Physiology, 2018, 233(4): 3375–3383. 2017. DOI: 10.1002/jcp.26184

Guo LL, Li L, Liu MY, Wan Q, Tian JW, Huang Q, Wen YQ, Liang SD (梁尚栋)*, Zhang XY*, Wei Y*: Bottom-up preparation of nitrogen doped carbon quantum dots with green emission under microwave-assisted hydrothermal treatment and their biological imaging. Materials Science and Engineering: C 2017; 60-66.

Jia T, Rao J, Zou L, Zhao S, Yi Z, Wu B, Li L, Yuan H, Shi L, Zhang C, Gao Y, Liu S, Xu H, Liu H, Liang S(梁尚栋)*, Li G. Nanoparticle-Encapsulated Curcumin Inhibits Diabetic Neuropathic Pain Involving the P2Y12 Receptor in the Dorsal Root Ganglia. Frontiers in neuroscience. 2017;11:755.

Yi ZH, Xie LH, Zhou CF, Yuan HL, Ouyang SA, Fang Z, Zhao SH, Jia TY, Zou LF, Wang SY, Xue Y, Wu B, Gao Y, Li GL,Liu SM, Xu H, Xu CS, Zhang CP, Liang SD(梁尚栋)*. P2Y12 receptor upregulation in satellite glial cells is involved in neuropathic pain induced by HIV glycoprotein 120 and 2′,3′-dideoxycytidine. Purinergic Signalling, 2018, 14(1), 47-58.

Yi Z, Ouyang S, Zhou C, Xie L, Fang Z, Yuan H, Yang J, Zou L, Jia T, Zhao S, Li L, Shi L, Gao Y, Li G, Liu S, Xu H, Xu C, Zhang C, Liang S(梁尚栋)*. Andrographolide Inhibits Mechanical and Thermal Hyperalgesia in a Rat Model of HIV-Induced Neuropathic Pain. Front. Pharmacol. 2018, 9:593. doi: 10.3389/fphar.2018.00593

Zou L, Han X, Liu S, Gong Y, Wu B, Yi Z, Liu H, Zhao S, Jia T, Li L, Yua H, Shi L, Zhang C, Gao Y, Li G, Xu H, Liang S(梁尚栋)*. Baicalin Depresses the Sympathoexcitatory Reflex Induced by Myocardial Ischemia via the Dorsal Root Ganglia. Front. Physiol. 2018, 9:928. doi: 10.3389/fphys.2018.00928

Yang R, Li L, Yuan H, Liu H, Gong Y, Zou L, Li S, Wang Z, Shi L, Jia T, Zhao S, Wu B, Yi Z, Gao Y, Li G, Xu H, Liu S, Zhang C, Li G, Liang S(梁尚栋)*. Quercetin relieved diabetic neuropathic pain by inhibiting upregulated P2X4 receptor in dorsal root ganglia. Journal of Cellular Physiology, J Cell Physiol. 2018 Aug 26. doi: 10.1002/jcp.27091.

Yuan H1, Ouyang S2, Yang R1, Li S2, Gong Y2, Zou L1, Jia T1, Zhao S1, Wu B1, Yi Z1, Liu H1, Shi L1, Li L1, Gao Y1, Li G1, Xu H1, Liu S1, Zhang C1, Liang S(梁尚栋)*. Osthole alleviated diabetic neuropathic pain mediated by the P2X4 receptor in dorsal root ganglia. Brain Res Bull. 2018 Aug 14;142:289-296. doi: 10.1016/j.brainresbull.2018.08.008. [Epub ahead of print].

Xue Y, Guo T, Zou L, Gong Y, Wu B, Yi Z, Jia T, Zhao S, Shi L, Li L, Yuan H, Liu H, Gao Y, Li G, Liu S, Xu H, Zhang C, Liang S(梁尚栋)*, Li G. Evodiamine attenuates P2X7-mediated inflammatory injury of human umbilical vein endothelial cells exposed to high free fatty acids. Oxidative Medicine and Cellular Longevity, 2018, accepted.

l 联系方式：

电话：15879098532

E-mail: liangsd88@163.com