张进 博士

南昌大学基础医学院教授、博士生导师

中央组织部"千人计划"青年项目

国家特聘专家

哈佛大学博士后

l 教育和工作背景:

2004 南昌大学生物科学专业 学士
2012 日本名古屋大学生物物理学学专业 博士
2012-2014 中国科学院上海药物研究所 博士后
2014-2017 哈佛大学医学院/HHMI 博士后
2017-至今 南昌大学基础医学院 教授、博士生导师

l 研究兴趣、领域：

课题组致力于人类重大疾病相关膜蛋白药物靶点的结构和基于结构的靶向药物研究。针对严重危害我国人民生命与健康的心脑血管疾病、肿瘤和精神神经等疾病，基于G蛋白偶联受体和离子通道的三维结构，进行抗中风、抗肿瘤和抗抑郁症等药物的研发。近年来在Nature、PNAS、Nature Communications、Developmental Cell、Cell Cycle等学术期刊发表论文多篇, 其中以第一作者或通讯作者在国际重要学术期刊上发表Nature（2篇）、PNAS（2篇）、    Nature Communications。

l 代表性论文：

1. Duan J, Li J, B Zeng, GL Chen, X Peng, Y Zhang, JB Wang, Clapham DE, Li Z, Zhang J^#. (2018). Structure of the mouse TRPC4 ion channel.Nature Communications Aug 6;9(1):3102. (# Corresponding author)

2. Duan J, Li Z, Li J, Hulse R, Santa-Cruz A, Valinsky W, Abiria S, Krapivinsky G, Zhang J^#, Clapham DE^#. (2018). Structure of the mammalian TRPM7, a magnesium channel required during embryonic development. Proc Natl Acad Sci U S A Aug 28;115(35):E8201-E8210. (# Corresponding author)

3. Duan J, Li Z, Li J, Santa-Cruz A, Sanchez-Martinez S, Zhang J^#, Clapham DE^#. (2018). Structure of full-length human TRPM4. Proc Natl Acad Sci U S A 115: 2377-82 (# Corresponding author)

4. Hulse RE, Li Z, Huang RK, Zhang J, Clapham DE. (2018). Cryo-EM structure of the polycystin 2-l1 ion channel. Elife 7

5. Cao J, Bollepalli MK, Hu Y, Zhang J, Li Q, Li H, Chang H, Xiao F, Hardie RC, Rong YS, Hu W. (2018). A Single Residue Mutation in the Galphaq Subunit of the G Protein Complex Causes Blindness in Drosophila. G3 (Bethesda) 8: 363-71

6. Song C, Yan H, Wang H, Zhang Y, Cao H, Wan Y, Kong L, Chen S, Xu H, Pan B, Zhang J, Fan G, Xin H, Liang Z, Jia W, Tian XL. (2018). AQR is a novel type 2 diabetes-associated gene that regulates signaling pathways critical for glucose metabolism. J Genet Genomics 45: 111-20

7. Chen, J., Fu, Y., Day, D. S., Sun, Y., Wang, S., Liang, X., Gu, F., Zhang, F., Stevens, S. M., Zhou, P., Li, K., Zhang, Y., Lin, R. Z., Smith, L. E. H., Zhang, J., Sun, K., Melero-Martin, J. M., Han, Z., Park, P. J., Zhang, B., Pu, W. T. (2017). VEGF amplifies transcription through ETS1 acetylation to enable angiogenesis. Nature Communications. 81, 383

8. Abiria, S. A., Krapivinsky, G., Sah, R.,Santa-Cruz, A. G.,Chaudhuri, D., Zhang, J., Adstamongkonkul, P., DeCaen, P. G., Clapham, D. E. (2017). TRPM7 senses oxidative stress to release Zn2+ from unique intracellular vesicles. Proc Natl Acad Sci, 114, 30, E6079-E6088

9. Lin, Z., Guo, H., Cao, Y., Zohrabian, S., Zhou, P., Ma, Q., VanDusen, N., Guo, Y., Zhang, J., Stevens, S.M., et al. (2016). Acetylation of VGLL4 Regulates Hippo-YAP Signaling and Postnatal Cardiac Growth. Dev Cell.

10. Zhang, J*., Zhang, K*., Gao, Z.G., Paoletta S., Zhang, D., Han, G.W., Li T., Ma L., Zhang W., Müller C.E., Yang H., Jiang H., Cherezov, V., Katritch, V., Jacobson, K.A., Stevens, R.C., Wu B., and Zhao Q. (2014). Agonist-bound structure of the human P2Y12 receptor. Nature, 509, 119-22. (*equally contributed to the work)

11. Zhang, K*., Zhang, J*., Gao, Z.-G., Zhang, D., Zhu, L., Han, G.W., Moss, S.M., Paoletta, S., Kiselev, E., Lu, W., et al. (2014). Structure of the human P2Y12 receptor in complex with an antithrombotic drug. Nature, 509, 115-8. (*equally contributed to the work)

12. Lu, H., Liu, B., Zhang, F.-J., Zhang, J., Dong, R., Chen, L., Qu, D.-M., Lu, Y., and Yu, B.-W. (2014). The E3 ligase APC/C-Cdh1 regulates MEF2A-dependent transcription by targeting SUMO-specific protease 2 for ubiquitination and degradation. Cell Cycle, 13(24):3892-902

13. Zhang, J., Mizuno, K., Murata, Y., Koide, H., Murakami, M., Ihara, K., and Kouyama, T. (2013). Crystal structure of deltarhodopsin-3 from Haloterrigena thermotolerans. Proteins 81, 1585-1592.

14. Zhang, J., Yamazaki, Y., Hikake, M., Murakami, M., Ihara, K., and Kouyama, T. (2012). Crystal structure of the O intermediate of the Leu93-->Ala mutant of bacteriorhodopsin. Proteins 80, 2384-2396.

15. Duan, J., Ishida, M., Aida, K., Tsuduki, T., Zhang, J., Manabe, Y., Hirata, T., and Sugawara, T. (2016). Dietary Cerebroside from Sea Cucumber (Stichopus japonicus): Absorption and Effects on Skin Barrier and Cecal Short-Chain Fatty Acids. J Agric Food Chem 64, 7014-7021.

l 所获项目、荣誉、奖励及参加学术团体的情况：

2017年 中央组织部"千人计划"青年项目（200万）

2017年 江西省海外引进高层次人才（500万）

2018年 国家自然科学基金面上项目“哺乳动物瞬时受体电位离子通道TRPM7的结构与功能研究”（60万）

2018年 江西省自然科学基金重点项目“人源镁离子通道蛋白TRPM6的三维结构解析及其与镁离子结合机制”（50万）

l 联系方式：

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E-mail: zhangxiaokong@hotmail.com

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