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导师李葆明


李葆明,男,中共党员,教授,博士生导师。19981月中国科学院上海生理研究所研究员;20011月复旦大学神经生物学研究所教授。2001年入选教育部长江学者奖励计划特聘教授,2002年获国家杰出青年科学基金资助,2007年入选上海市领军人才计划,200812月南昌大学教授、副校长2009年入选江西省主要学科和技术带头人,2010年入选首批江西省赣鄱英才555工程领军人才计划。享受国务院政府特殊津贴(1995年)。

长期从事脑科学研究,在学习记忆及儿童多动症的神经机制研究方面取得显著成绩。先后主持国家973项目课题、863项目、国家自然科学基金重大项目和重点项目、中国-加拿大健康研究合作项目等。作为主要作者在Neuron, Biological Psychiatry, PNAS, Cerebral Cortex等国际著名刊物发表研究论文65篇。获2009年上海市自然科学奖二等奖(排名第一)、2014年江西省自然科学奖一等奖(排名第一)。

中国生理学会副理事长、科普工作委员会主任委员;中国神经科学学会常务理事;中国生物物理学会理事;江西省医学会副会长;江西省神经科学学会理事长;谈家桢生命科学奖评审专家委员会委员;国家自然科学基金委员会生命科学部学科评审组成员;全国高等医学教育学会临床医学教育研究会常务理事;中国医师协会整合医学专业委员会常务委员;中华医学会医学教育分会委员。


承担的国家级科研项目

1. 2015.01-2018.12:课题负责人,国家自然科学基金委面上项目母婴分离对前额叶皮层髓鞘发育与认知功能的影响81471116),80万元

2. 2013.01-2016.12:课题负责人,国家自然科学基金委面上项目猴前额叶皮层神经元在序列计数操作中的作用31271171),80万元

3. 2010.01-2014.05:课题负责人,国家自然科学基金委重大项目额叶和海马环路的形成及其信息处理30990260),1000万元

4. 2011.01-2012.12:课题负责人,科技部973项目课题高级脑认知功能的环路基础2011CBA00406),450万元

5. 2007.1-2009.12:课题负责人,国家基金委中国-加拿大健康研究合作项目小鼠和猴认知记忆的前额叶皮层机制研究30611120530),45万元

6. 2006.1-2010.12:课题负责人,科技部973项目课题长时记忆的集群神经元编码2006CB500807),260万元

7. 2006.1-2008.12:课题负责人,科技部863项目学习记忆相关基因及其信号转导通路2006AA02Z199),200万元

8. 2005.1-2008.12:课题负责人,国家自然科学基金委重点项目海马和杏仁体b受体在学习和记忆中作用30430240),150万元

9. 2003.1-2006.12:课题负责人,国家杰出青年科学基金项目前额叶皮层a2受体与行为抑制功能30225023),100万元

10. 2002.1-2005.12:课题负责人,科技部863项目大脑学习和记忆相关基因的研究160万元

11. 1999.1-2004.12:课题负责人,科技部973项目课题脑高级功能的机制G1999054000),330万元


承担的省部级科研项目

12. 2017.01-2020.12:课题负责人,江西省自然科学基金面上重点项目囊性纤维化跨膜调控因子(CFTR)在前额叶皮层认知功能中的作用50万元

13. 2013.01-2015.12:课题负责人,江西省高等院校科技落地计划项目儿童多动症的药物开发与行为干预技术研究KJLD12015),50万元

14. 2011.01-2013.12:课题负责人,江西省政府人才计划项目江西省赣鄱英才555工程领军人才培养计划18000005),100万元

15. 2010.01-2013.12:课题负责人,江西省主要学科学术和技术带头人项目多动症的神经元胞内信号机制2009DD01100),20万元

16. 2014.01-2017.12:团队负责人,江西省科技条件平台建设项目江西省神经科学重点实验室20142BCD40003),50万元

17. 2014.01-2016.12:团队负责人,江西省优势科技创新团队建设计划项目神经精神疾病的发病机制及防治策略20142BCB24002),30万元

18. 2012.01-2014.12:团队负责人,江西省优势科技创新团队建设计划项目神经精神疾病的基础与临床研究20113BCB24022),20万元


获奖及专利

l 2014年,获江西省自然科学奖一等奖,名称:认知记忆的去甲肾上腺素能调控(排名第一),证书号:Z-14-1-02-R01

l 2009年,获上海市自然科学奖二等奖,名称:前额叶皮层alpha-2受体在认知功能中的作用(排名第一),证书号:20092032-2-R01

l 2013年,获实用新型专利,名称:一种用于猴房的猴子排污清洗装置,专利号:ZL 2013 2 0402497.


主要发表文章(*通讯作者)

1. Hui-Feng Jiao, Xiang-Dong Sun, R. Bates, Lei Xiong, Fang Liu, Lei Li, Hong-Seng Zhang, Shun-Qi Wang, Ming-Tao Xiong, Mihir Patel, Alexis M. Stranahan, Wen-Cheng Xiong, Bao-Ming Li*, Lin Mei* (2017). Transmembrane protein 108 is required for glutamatergic transmission in dentate gyrus. Proceedings of the National Academy of Sciences of the United States of America (Nat. Acad. Sci. USA). 114 (5): 1177-1182.

2. Shuai Wang, Yi Shi, Bao-Ming Li* (2017). Neural Representation of Cost-Benefit Selections in Rat Anterior Cingulate Cortex in Self-Paced Decision Making. Neurobiology of Learning and Memory, 139: 1-10.

3. You-Jun Yang, Zong-Yue Cheng, Hua Tang, Hui-Feng Jiao, Xuan Sun, Qiu-Zhu Cui, Fei Luo, Hai-Li Pan, Chao-Lin Ma, Bao-Ming Li* (2016). Neonatal Maternal Separation Impairs Prefrontal Cortical Myelination and Cognitive Functions in Rats Through Activation of Wnt Signaling. Cerebral Cortex, 26 (6): 1-14.

4. Shuai Wang, Shan-Hu Hu, Yi Shi, Bao-Ming Li* (2016). The roles of the anterior cingulate cortex and its dopamine receptors in self-paced cost-benefit decision making in rats. Learning & Behavior,1-11.

5. Bao-Ming Li*, Shintaro Funahashi (2015). A step forward in the understanding of prefrontal cortical functions. Neuroscience Bulletin, 31(2): 161–163.

6. Qi Wang, Sheng-Tao Yang, Bao-Ming Li* (2015). Neuronal representation of audio-place associations in the medial prefrontal cortex of rats. Molecular Brain, 8: 56.

7. Sheng-Tao Yang, Yi Shi, Qi Wang, Ji-Yun Peng and Bao-Ming Li* (2014). Neuronal representation of working memory in the medial prefrontal cortex of rats. Molecular Brain, 7:61.

8. Yue Liu, Xing Liang, Wen-Wen Ren, Bao-Ming Li* (2014). Expression of β1- and β2-adrenoceptors in different subtypes of interneurons in the medial prefrontal cortex of mice. Neuroscience, 257:149-157.

9. Hu Lu, Sheng-Tao Yang, Long-Nian Lin, Bao-Ming Li*, Hui Wei* (2013). Prediction of Rat Behavior Outcomes in Memory Tasks Using Functional Connections among Neurons. PLoS ONE, 8 (9): e74298.

10. Feng Yi, Xue-Han Zhang, Charles R. Yang, Bao-Ming Li* (2013). Contribution of Dopamine D1/5 Receptor Modulation of Post-Spike/Burst Afterhyperpolarization to Enhance Neuronal Excitability of Layer V Pyramidal Neurons in Prepubertal Rat Prefrontal Cortex. PLoS ONE, 8 (8): e71880.

11. Feng Yi, Shu-Su Liu, Fei Luo, Xue-Han Zhang*, Bao-Ming Li* (2013). Signaling mechanism underlying α2A-adrenergic suppression of excitatory synaptic transmission in the medial prefrontal cortex of rats. European Journal of Neuroscience, 38 (3): 2364-2373.

12. Hou-Cheng Zhou, Yan-Yan Sun, Wei Cai, Xiao-Ting He, Feng Yi, Bao-Ming Li*, Xue-Han Zhang* (2013). Activation of β2-adrenoceptor enhances synaptic potentiation and behavioral memory via cAMP-PKA signaling in the medial prefrontal cortex of rats. Learning & Memory, 20: 274-284.

13. Xue-Han Zhang*, Shu-Su Liu, Feng Yi, Min Zhuo, Bao-Ming Li* (2013). Delay-dependent impairment of spatial working memory with inhibition of NR2B-containing NMDA receptors in hippocampal CA1 region of rats. Molecular Brain, 6: 13.

14. Chun-Lei Zhang, Ze-Jun Feng, Yue Liu, Xiao-Hua Ji, Ji-Yun Peng, Xue-Han Zhang, Xue-Chu Zhen, Bao-Ming Li* (2012). Methylphenidate Enhances NMDA-Receptor Response in Medial Prefrontal Cortex via Sigma-1 Receptor: A Novel Mechanism for Methylphenidate Action. PLoS ONE, 7 (12): e51910.

15. Wen-Wen Ren, Yue Liu, Bao-Ming Li* (2012). Stimulation of α2A-adrenoceptors promotes the maturation of dendritic spines in cultured neurons of the medial prefrontal cortex. Molecular and Cellular Neuroscience, 49: 205-216.

16. Li Sui, Wen-Wen Ren and Bao-Ming Li* (2010). Administration of thyroid hormone increases reelin and brain-derived neurotrophic factor expression in rat hippocampus in vivo. Brain Research, 1313: 9-24.

17. Peng JY, Bao-Ming Li* (2009). Protein synthesis is essential not only for consolidation but also for maintenance and post-retrieval reconsolidation of acrobatic motor skill in rats. Molecular Brain, 2:12.

18. Xiao-Hua Ji, Xiao-Hua Cao, Chun-Lei Zhang, Ze-Jun Feng, Xue-Han Zhang, Lan Ma, and Bao-Ming Li* (2008). Pre- and post-synaptic b-adrenergic activation enhances excitatory synaptic transmission in layer V/VI pyramidal neurons of the medial prefrontal cortex of rats. Cerebral Cortex, 18: 1506-1520.

19. Xiao-Hua Ji, Jin-Zhao Ji, Hui Zhang and Bao-Ming Li* (2008). Stimulation of a2-adrenoceptors suppresses excitatory synaptic transmission in the medial prefrontal cortex of rat. Neuropsychopharmacology, 33: 2263-2271.

20. Li-li Qu, Nan-nan Guo, and Bao-Ming Li* (2008). b1- and b2-adrenoceptors in basolateral nucleus of amygdala and their roles in consolidation of fear memory in rats. Hippocampus, 18: 1131-1139.

21. Li Sui, Jing Wang and Bao-Ming Li* (2008). Role of phosphoinositide 3-kinase-Akt-mammalian target of rapamycin signaling pathway in long-term potentiation and trace fear conditioning memory in rat medial prefrontal cortex. Learning and Memory, 15: 762-776.

22. Sui, L., Wang, J. & Bao-Ming Li * (2008). Administration of triiodo-L-thyronine into dorsal hippocampus alters phosphorylation of Akt, mammalian target of rapamycin, p70S6 kinase and 4E-BP1 in rats. Neurochemical research, 33, 1065-1076.

23. Xue-Han Zhang, Long-Jun Wu, Bo Gong, Ming Ren, Bao-Ming Li* and Min Zhuo* (2008). Induction- and conditioning-protocol dependent involvement of NR2B-containing NMDA receptors in synaptic potentiation and contextual fear memory in the hippocampal CA1 region of rats. Molecular brain, 1, 9.

24. Qi, X. L., Zhu, B., Zhang, X. H. & Bao-Ming Li * (2008). Are beta-adrenergic receptors in the hippocampal CA1 region required for retrieval of contextual fear memory? Biochemical and biophysical research communications, 368, 186-191.

25. Xue-Han Zhang, Fang Liu, Qian Chen, Chun-Lei Zhang, Min Zhuo, Zhi-Qi Xiong, Bao-Ming Li* (2008). Conditioning-strength dependent involvement of NMDA NR2B subtype receptor in the basolateral nucleus of amygdala in acquisition of auditory fear memory. Neuropharmacology, 55: 238-246.

26. ZHENG XinLing, LIU Fang, WU XingWen, Bao-Ming Li* (2008). Infusion of methylphenidate into the basolateral nu-cleus of amygdala or anterior cingulate cortex en-hances fear memory consolidation in rats. Science in China Series C: Life Sciences, 51 (9): 1-6.

27. Xin-Chun Jin, Yu-Fei Lu, Xiao-Fei Yang, Lan Ma and Bao-Ming Li * (2007). Glucocorticoid receptor in the basolateral nucleus of amygdala is required for post-reactivation reconsolidation of auditory fear memory. European Journal of Neuroscience, 25: 3702-3712.

28. Nan-Nan Guo and Bao-Ming Li* (2007). Cellular and subcellular distribuions of b1- and b2-adrenoceptors in the CA1 and CA3 regions of the rat hippocampus. Neuroscience, 146: 298-305.

29. Xin-Ming Wang, Xiang Gao, Xue-Han Zhang, Yan-Yang Tu, Mei-Lei Jin, Guo-Ping Zhao, Lei Yu, Nai-He Jing, Bao-Ming Li* (2006). The negative cell cycle regulator, Tob (transducer of ErbB-2), is involved in motor skill learning. Biochemical and biophysical research communications, 340, 1023-1027.

30. Qiu-Ling Hou, Xiang Gao, Qi Lu, Xue-Han Zhang, Yan-Yang Tu, Mei-Lei Jin, Guo-Ping Zhao, Lei Yu, Nai-He Jing, Bao-Ming Li* (2006). SNAP-25 in hippocampal CA3 region is required for long-term memory formation. Biochemical and biophysical research communications, 347, 955-962.

31. Ming-Gao Zhao, Hiroki Toyoda, Yong-Seok Lee, Long-Jun Wu, Shanelle W. Ko, Xue-Han Zhang, Yongheng Jia, Fanny Shum, Hui Xu, Bao-Ming Li*, Bong-Kiun Kaang and Min Zhuo* (2005). Roles of NMDA NR2B subtype receptor in prefrontal long-term potentiation and contextual fear memory. Neuron, 47: 859-872.

32. Ma CL, Arnsten AFT, Bao-Ming Li* (2005). Locomotor hyperactivity induced by blockade of prefrontal cortical a2-adrenoceptors in monkeys. Biological Psychiatry, 57(2): 192-195.

33. Xue-Han Zhang, Hui Zhang, Yanyang Tu, Xiang Gao, Changfu Zhou, Meilei Jin, Guoping Zhao, Naihe Jing*, Bao-Ming Li*, Lei Yu* (2005). Identification of a novel protein for memory regulation in the hippocampus. Biochemical and biophysical research communications, 334, 418-424.

34. M. Jin, X.-M. Wang, Y. Tu, X.-H. Zhang, X. Gao, N. Guo, Z. Xie, G. Zhao, N. Jing*, Bao-Ming Li*, L. Yu* (2005). The negative cell cycle regulator, Tob (transducer of ErbB-2), is a multifunctional protein involved in hippocampus-dependent learning and memory. Neuroscience, 131, 647-659.

35. M. Wang, J.-Z. Ji and Bao-Ming Li* (2004). The alpha-2A adrenergic agonist guanfacine improves visuomotor association learning in monkeys. Neuropsychopharmacology, 29: 86-92.

36. M. Wang, Z.-X. Tang and Bao-Ming Li* (2004). Enhanced visuomotor associative learning following stimulation of alpha 2A-adrenoceptors in the ventral prefrontal cortex in monkeys. Brain research, 1024, 176-182.

37. J.-Z. Ji, X.-M. Wang and Bao-Ming Li* (2003). Deficit in long-term contextual fear memory induced by blockade of b -adrenoceptors in hippocampal CA1 region. European Journal of Neuroscience, 17: 1947-1952.

38. Ji, J. Z., Zhang, X. H. & Bao-Ming Li* (2003). Deficient spatial memory induced by blockade of beta-adrenoceptors in the hippocampal CA1 region. Behavioral neuroscience, 117, 1378-1384.

39. Ma, Chao‐Lin; Qi, Xue‐Lian; Peng, Ji‐Yun; Bao-Ming Li* (2003). Selective deficit in no‐go performance induced by blockade of prefrontal cortical α2‐adrenoceptors in monkeys. Neuroreport, 14(7): 1013-1016.

40. M. Wang, H. Zhang and Bao-Ming Li* (2000). Deficit in conditional visuomotor learning by local infusion of bicuculline into the ventral prefrontal cortex in monkeys. European Journal of Neuroscience, 12:3787-3796.

41. Bao-Ming Li*, Z.-M. Mao, M. Wang, and Z.-T. Mei (1999). Alpha-2 aderenergic modulation of prefrontal cortical neuronal activity related to spatial working memory in monkeys. Neuropsychopharmacology, 21:601-610.

42. Z.-M. Mao, AFT Arnsten and Bao-Ming Li* (1999). Local infusion of an alpha-1 adrenergic agonist into the prefrontal cortex impairs spatial working memory performance in monkeys. Biological Psychiatry, 46:1259-1265.

43. Amy F.T Arnsten, Rex Mathew, Ravi Ubriani, Jane R Taylor, Bao-Ming Li* (1999). Alpha-1 noradrenergic receptor stimulation impairs prefrontal cortical cognitive function. Biological Psychiatry, 45(1): 26-31.

44. Bao-Ming Li, Kisou Kubota (1998). alpha-2 adrenergic modulation of prefrontal cortical neuronal activity related to a visual discrimination task with GO and NO-GO performances in monkeys. Neuroscience research, 31:83-95.

45. Arnsten AF, Steere JC, Jentsch DJ, Bao-Ming Li* (1998). Noradrenergic influences on prefrontal cortical cognitive function: opposing actions at postjunctional alpha 1 versus alpha 2-adrenergic receptors. Advances in Pharmacology. 42: 764-767.

46. Bao-Ming Li, Zhen-Tong Mei (1994). Delayed-response deficit induced by local injection of the α2-adrenergic antagonist yohimbine into the dorsolateral prefrontal cortex in young adult monkeys. Behavioral and Neural Biology. 62 (2): 134–139.

47. Bao-Ming Li, Matsumura, M. & Kubota, K. GABAB modulation of neuronal activity related to visually guided movement in the monkey premotor cortex. Neuroscience research, 18, 83-87 (1993).

48. Bao-Ming Li, Mei, Z. T. & Kubota, K. Multibarreled glass-coated tungsten microelectrode for both neuronal activity recording and iontophoresis in monkeys. Neuroscience research, 8, 214-219 (1990).




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