张敏
张敏,女,1980年2月生,博士,教授
所属学科:水产养殖; 研究方向:鱼类免疫与病害防治
教育经历:(从本科起,含出国访学)
2006年9月–2009年6月:中国科学院大学,海洋生物学,获理学博士学位
2001年9月–2004年6月:湛江海洋大学,水产养殖,获农学硕士学位
1997年9月-2001年6月:莱阳农学院,海水养殖,获农学学士学位
近五年科研成果总结介绍:
主要从事鱼类免疫与病害防治研究工作,研究了多个鱼类免疫因子的应答机制,研制出多种具广谱抗菌活性的抗菌肽并探讨了其抗菌机制。发表SCI论文20余篇,其中第一/通讯作者论文14篇,获授权发明专利4项,获国家海洋局海洋创新成果二等奖和青岛市自然科学二等奖各1项。
近五年代表成果列表:(限10项)
1 He SW, Wang JJ, Du X, Yue B, Wang GH, Zhou S, Xie B,Zhang M*. A teleost TFPI-2 peptide that possesses a broad antibacterial spectrum and immune-stimulatory properties. Fish Shellfish Immunol. 2018, 82:469–475.
2 Du X, Wang G, Su Y,Zhang M*, Hu YH*. Black rockfish C-type lectin, SsCTL4: a pattern recognition receptor that promotes bactericidal activity and virus escape from host immune defense. Fish Shellfish Immunol. 2018, 79:340–350.
3 He SW, Wang GH, Yue B, Zhou S,Zhang M*. TO17: a teleost antimicrobial peptide that induces degradation of bacterial nucleic acids and inhibits bacterial infection in red drum,Sciaenops ocellatus. Fish Shellfish Immunol. 2018, 72:639–645.
4 Wang GH, Jiang ZJ, He SW,Zhang M*. Two novel calreticulin-related molecules with microbial binding and phagocytosis enhancing capacity in the half-smooth tongue sole,Cynoglossus semilaevis. Fish Shellfish Immunol. 2018, 72:174–180.
5 Zhang M, Yue B, Zhang AH, Wang GH, Liu Y, Zhou S, Cheng SF, Li NQ. TC38, a teleost TFPI-2 peptide that kills bacteria via penetration of the cell membrane and interaction with nucleic acids. Fish Shellfish Immunol. 2017, 64:104–110.
6 He S, Zhang J, Li N, Zhou S, Yue B,Zhang M*, A TFPI-1 peptide that induces degradation of bacterial nucleic acids, and inhibits bacterial and viral infection in half-smooth tongue sole,Cynoglossus semilaevis. Fish Shellfish Immunol. 2017, 60:466–473.
7 Zhao X, He S, Yue B, Wang G,Zhang M*. Molecular characterization, expression analysis, and bactericidal activity of the derivative peptides of TFPI-1 and TFPI-2 in half-smooth tongue sole,Cynoglossus semilaevis. Fish Shellfish Immunol. 2016, 58:563–571.
8 Liu Y, Li N, Zhao X, Yue B, He S, Gao Z, Zhou S,Zhang M*. A C-type lectin that inhibits bacterial infection and facilitates viral invasion in black rockfish,Sebastes schlegelii.Fish Shellfish Immunol. 2016, 57:309–317.
9 Zhao X, Hu Y, Liu Y, Wang J, Wang G, Wang R,Zhang M*. A High mobility group box 1 that binds to DNA, enhances pro-inflammatory activity, and acts as an anti-infection molecule in black rockfish, Sebastes schlegelii. Fish Shellfish Immunol. 2016, 56:402–409.
10 Sun BG,Zhang M*. Analysis of the antibacterial effect of anEdwardsiella tarda LuxS inhibitor. SpringerPlus. 2016, 5:92.
近五年主持科研项目:(限5项)
1. “水产动物疫病发生的分子基础与免疫机制”项目子课题“宿主免疫效应因子与抗感染免疫稳态调控”;国家重点研发计划“蓝色粮仓科技创新”专项。
2. 半滑舌鳎TFPI-2衍生抗菌肽在制备新型灭活疫苗中的应用研究,国家自然科学基金面上项目(31872607)。
3. 海水鱼类病原及相关候选疫苗对南方热带鱼类和北方温/冷水鱼类的差异效应比较研究,中国热带农业科学院开放课题。
4. 美国红鱼TFPI衍生肽的抗菌机制研究,国家自然科学基金面上项目(31572652)。
5. 重要经济水产动物抗菌肽基因的克隆、表达及功能研究,青岛农业大学博士启动基金项目。
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