电子邮箱：lili@hznu.edu.cn

电话：0571－28865729

研究方向： 利用小鼠模式生物，通过细胞生物学、生物化学及分子生物学方法研究调控细胞衰老的分子机制。 

通讯地址：浙江省杭州市文一西路1378号杭师大科技园D615

个人简历：

05/2013 至今          杭师大医学院衰老所教授   

07/2011-01/2013    美国桑福德伯纳姆医学研究所Dr. Randal J. Kaufman实验室博士后

09/2005-05/2011     美国密歇根大学生物化学系博士研究生

09/2003-07/2005    中科院上海植物生理生态研究所研究生（后因为出国退学）

09/1999-07/2003     浙江大学生命科学学院生物科学与技术系 本科

科研项目：

1. ｹ恝ﾒﾗﾔﾈｻｿﾆﾑｧｻ鹎嗄晗鍗ｿ（81401144）（ﾖﾖﾈﾋ）：PTEN－端粒互作调控细胞衰老的机制研究，2015.01-2017.12, 23万

2. ｹ恝ﾒﾗﾔﾈｻｿﾆﾑｧｻ賈ﾏ项ﾄｿ（81571375）（ﾖﾖﾈﾋ）：PTEN-端粒互作调控卵巢衰老机制研究，2016.01-2019.12, 57ﾍò

论ﾎﾄ专ﾖº

1.        X. Dai, H. Liu, S. Shen, X. Guo, H. Yan, X. Ji, L. Li, J. Huang, X.H. Feng, B. Zhao, YAP activates the Hippo pathway in a negative feedback loop. Cell Res., 25 (2015), pp. 1175–1178

2.        Shen S., Guo X., Yan H., Lu Y., Ji X., Li L., Liang T., Zhou D., Feng X.H., Zhao J.C., et al. A miR-130a-YAP positive feedback loop promotes organ size and tumorigenesis. Cell Res. 2015;25:997–1012.

3.        Zhou Q., Li L., Zhao B., Guan K. L. (2015). The hippo pathway in heart development, regeneration, and diseases. Circ. Res. 116, 1431–1447.

4.        Deng L. et al. The ubiquitination of rag A GTPase by RNF152 negatively regulates mTORC1 activation. Mol. Cell. 58, 804–818 (2015).

5.        Hong-Ling Huang, Shimin Wang, Meng-Xin Yin, Liang Dong, Chao Wang, Wei Wu, Yi Lu, Miao Feng, Chuanyang Dai, Xiaocan Guo, Li Li, Bin Zhao, Zhaocai Zhou, Hongbin Ji, Jin Jiang, Yun Zhao, Xin-Yuan Liu, and Lei Zhang (2013) Par-1 regulates tissue growth by influencing hippo phosphorylation status and hippo-salvador association. PLoS Biol 11, e1001620

6.          Li, L., and Guan, K. L. (2013) Microtubule-associated protein/microtubule affinity-regulating kinase 4 (MARK4) is a negative regulator of the mammalian target of rapamycin complex 1 (mTORC1). J Biol Chem 288, 703-708.

7.          Zhao, B., Li, L., Wang, L., Wang, C. Y., Yu, J., and Guan, K.L. (2012) Cell detachment activates the Hippo pathway via cytoskeleton reorganization to induce anoikis. Genes Dev 26, 54-68.

8.          Gong, R.*, Li, L.*, Liu, Y.*, Wang, P., Yang, H., Wang, L., Cheng, J., Guan, K-L., and Xu, Y. (2011) Crystal Structure of Gtr1p-Gtr2p complex reveals new insights into the amino acid-induced TORC1 activation. Genes Dev 25, 1668-73. (* equal contribution)

9.          Zhao, B. *, Li, L. *, Lu, Q., Wang, L. H., Liu, C-Y., Yi, C., Kissil, J. L., Lei, Q., and Guan, K.L. (2011) Angiomotin is a novel Hippo pathway component that inhibits YAP oncoprotein. Genes Dev 25, 51-63. (* equal contribution)

10.       Zhao, B., Li, L., and Guan, K.L. (2010) Hippo signaling at a glance. J Cell Sci 123, 4001-6.

11.     Li, L., and Guan, K. L. (2010) Rag GTPases in TORC1 Activation and Nutrient Signaling, The Enzymes 27, 75-87

12.       Li, L., Kim, E., Yuan, H., Inoki, K., Goraksha-Hicks, P., Schiesher, R. L., Neufeld, T. P., and Guan, K. L. (2010) Regulation of mTORC1 by the Rab and Arf GTPases, J Biol Chem 285, 19705-19709.

13.       Zhao, B., Li, L., Tumaneng, K., Wang, C. Y., and Guan, K. L. (2010) A coordinated phosphorylation by Lats and CK1 regulates YAP stability through SCF(beta-TRCP), Genes Dev 24, 72-85.

14.       Zhao, B., Li, L., Lei, Q., and Guan, K. L. (2010) The Hippo-YAP pathway in organ size control and tumorigenesis: an updated version, Genes Dev 24, 862-874.

15.       Li, L., and Guan, K. L. (2009) Amino acid signaling to TOR activation: Vam6 functioning as a Gtr1 GEF, Mol Cell 35, 543-545.

16.       Zhou, X., Ikenoue, T., Chen, X., Li, L., Inoki, K., and Guan, K. L. (2009) Rheb controls misfolded protein metabolism by inhibiting aggresome formation and autophagy, Proc Natl Acad Sci U S A 106, 8923-8928.

17.       Kim, E., Goraksha-Hicks, P., Li, L., Neufeld, T. P., and Guan, K. L. (2008) Regulation of TORC1 by Rag GTPases in nutrient response, Nat Cell Biol 10, 935-945.

18.       Zhao, B., Ye, X., Yu, J., Li, L., Li, W., Li, S., Lin, J. D., Wang, C. Y., Chinnaiyan, A. M., Lai, Z. C., and Guan, K. L. (2008) TEAD mediates YAP-dependent gene induction and growth control, Genes Dev 22, 1962-1971.

19.       Zhao, B., Wei, X., Li, W., Udan, R. S., Yang, Q., Kim, J., Xie, J., Ikenoue, T., Yu, J., Li, L., Zheng, P., Ye, K., Chinnaiyan, A., Halder, G., Lai, Z. C., and Guan, K. L. (2007) Inactivation of YAP oncoprotein by the Hippo pathway is involved in cell contact inhibition and tissue growth control, Genes Dev 21, 2747-2761.

20.       Howell, V. M., Jones, J. M., Bergren, S. K., Li, L., Billi, A. C., Avenarius, M. R., and Meisler, M. H. (2007) Evidence for a direct role of the disease modifier SCNM1 in splicing, Hum Mol Genet 16, 2506-2516.

21.    Huang, H.L., Wang, S., Yin, M.X., Dong, L., Wang, C., Wu, W., Lu, Y., Feng, M., Dai, C., Guo, X., Li, L., Zhao, B., Zhou, Z., Ji, J., Zhao, Y., Liu, X.Y., Zhang, L. (2013) Par-1 regulates tissue growth by influencing hippo phosphorylation status and hippo-salvador association. PLoS Biol 11, 1-15.