职   务：杭州市“西湖学者”入选者，中国生物物理学会，浙江省转化医学学会会员

导师类别：硕士生导师

联系电话：(0571) 28861723

E-mail：xuxl@hznu.edu.cn

通讯地址：浙江省杭州市文一西路1378号杭州师范大学科技园D座615，311121

研究方向：重要生物大分子的三维空间结构与功能研究

个人简历：

2000.9-2004.7  兰州大学，生物学，学士

2004.9-2008.7  清华大学，生物物理学，博士

2009.1-2013.1   美国Scripps研究所，Research Associate

2013.2-至今  杭州师范大学医学院衰老研究所，特聘教授

研究领域：

长期从事人类重大疾病相关生物大分子的三维结构和功能研究，在蛋白质药物设计、酶工程方面具有丰富经验，在国际上首次解析了多个重要生物大分子的三维晶体结构，在国际知名期刊发表高水平SCI论文18篇。目前主要从事人源氨酰tRNA合成酶在肿瘤心血管生成中的分子机制研究及药物研发。

科研项目

1.   光合玫瑰菌核心光合复合体的结构与功能研究，国家基金面上项目，2016.01-2019.12，62万元，主持

2.  色氨酰tRNA合成酶抑制新血管生成的分子机制，国家基金青年项目，2015.01-2017.12，25万元，主持

3.  色氨酰tRNA合成酶抑制肿瘤新血管生成的分子机制研究，浙江省自然科学基金项目，2014.01-2016.12，10 万元，主持

4. “杭州市创新药物研究” 重中之重实验室经费，2014.01-2016.12，120万元

5. 结核分枝杆菌麦芽糖激酶MaK的结构和功能研究，2015.01-2016.01，5万元，主持

代表性论文：

1.   Sun X, He G, Wang X, Xu S, Ju J*, Xu X*(Corresponding author).Crystalstructure of a thermostable alanine racemase from Thermoanaerobacter tengcongensis MB4 reveals the role of Gln360 in substrate selection. PLoS One. 2015, 10(7):e0133516. (IF: 3.234)

2.  Sun X, Liu X, Wang X, Ni X, Yuan Z, Yang L, Xu X*(Corresponding author). Enzymatic and preliminary X-ray Crystallographic characterizations of human Tryptophanyl-tRNA synthetase H130R mutant. Acta Biophysica Sinica. 2015, 31 (3):1-12.

3. Hou H, Li R, Yuan Z, Wang X, Liu X, Chen Z, Xu X*(Corresponding author). Crystallographic analysis of a novel aldo-keto reductase from Thermotoga maritima in complex with NADP⁺. Acta Crystallogr F. 2015, 71 (Pt 7):847-55. (IF:0.527)

4. Zhu L, Xu X, Wang L, Dong H, Yu B, Ma Y. NADP+-Preferring d-Lactate Dehydrogenase from Sporolactobacillus inulinus. Appl Environ Microbiol. 2015, pii: AEM.01871-15. (IF: 3.668)

5. Zhu L, Xu X, Wang L, Dong H, Yu B, Ma Y. The D-Lactate Dehydrogenase from Sporolactobacillus inulinus also Possessing Glutamate Dehydrogenase Activity. PLoS One. 2015 (Accepted) (IF: 3.234).

6. Li J, Guan X, Shaw N, Chen W, Dong Y, Xu X, Li X, Rao Z. Homotypic dimerization of a maltose kinase for molecular scaffolding. Sci Rep. 2014, 23(4):6418. (IF: 5.578)

7. Shi Y, Xu X, Zhang Q, Fu G.S., Mo Z.Y., Wang George S, Kishi S, Yang X.L. tRNA synthetase counteracts c-Myc to develop functional vasculature. eLife. 2014,3:e02349. (IF:9.322)

8. Xu X, Shi Y, Yang X.L. Crystal structure of human serine tRNA synthetase and Ser-SA complex reveals a molecular lever specific to higher eukaryotes. Structure. 2013, 21(11):2078-86. (IF:5.618)

9. Xu X*, Shi Y*, Zhang HM, Swindell EC, Marshall AG, Guo M, Kishi S,Yang XL. Unique domain appended to vertebrate tRNA synthetase is essential for vascular development. Nat Commun. 2012, 3:681. (IF:11.470)

10. Zhou Q, Kapoor M, Guo M, Belani R, Xu X, Kiosses WB, Hanan M, Park C, Armour E, Do MH, Nangle LA, Schimmel P, Yang XL. Orthogonal use of a human tRNA synthetase active site to achieve multifunctionality. Nat Struct Mol Biol. 2010, 17(1): 57-61. (IF:13.309)

11. Xu X, Lou Z, Ma Y, Chen X, Yang Z, Tong X, Zhao Q, Xu Y, Deng H, Bartlam M, Rao Z. Crystal structure of the C-terminal cytoplasmic domain of non-structural protein 4 from mouse hepatitis virus A59. PLoS One. 2009, 4(7): e6217. (IF:3.234)

12. Xu X, Zhai Y, Sun F, Lou Z, Su D, Xu Y, Zhang R, Joachimiak A, Zhang XC, Bartlam M & Rao Z*. New antiviral target revealed by the hexameric structure of mouse hepatitis virus nonstructural protein nsp15. J Virol. 2006, 80(16): 7909-7917. (IF:4.439)

13. Ma Y, Tong X, Xu X, Li X, Lou Z, Rao Z. Structures of the N- and C-terminal    domains of MHV-A59 nucleocapsid protein corroborate a conserved RNA-protein binding mechanism in coronavirus. Protein Cell. 2010, 1(7): 688-97. (IF:3.247)

14. Xu Y, Cong L, Chen C, Wei L, Zhao Q, Xu X, Ma Y, Bartlam M, Rao Z. Crystal structures of two coronavirus ADP-ribose-1''-monophosphatases and their complexes with ADP-Ribose: a systematic structural analysis of the viral ADRP domain. J Virol. 2009, 83(2): 1083-92. (IF:4.439)

15. Dong H, Lou Z, Xu X, Su D, Zhou X, Li X, Bartlam M. Crystallization and preliminary crystallographic analysis of recombinant human calcyphosine. Protein Pept Lett. 2009, 16(3): 339-41. (IF:1.068)

16. Dong H, Li X, Lou Z, Xu X, Su D, Zhou X, Zhou W, Bartlam M, Rao Z. Crystal-structure and biochemical characterization of recombinant human calcyphosine delineates a novel EF-hand-containing protein family. J Mol Biol. 2008, 383(3): 455-64. (IF:4.333)

17.Wei L, Chen C, Zhao Q, Li C, Cong L, Xu X, Ma Y, Liao M, Xu Y, Rao Z. Purification, crystallization and preliminary crystallographic analysis of avian infectious bronchitis virus nsp3 ADRP domain. Acta Crystallogr, F. 2008, 64(Pt 9): 802-4. (IF:0.527)

18. Zhai Y, Sun F, Li X, Pang H, Xu X, Bartlam M, & Rao Z*. Structural insights into coronavirus transcription/replication from the crystal structure of the SARS-CoV hexadecameric Nsp7•Nsp8 super-complex. Nat Struct Mol Biol, 2005, 12(11): 980-986. (IF:13.309)