一、 个人简历

冯琛卓，女，1980年生，浙江平湖人，博士，讲师, 硕导。

1998 – 2002年，浙江大学生命科学学院生物科学专业，理学学士

2002 – 2007年，浙江大学生命科学学院生物化学与分子生物学专业，理学博士

2007-2008年，浙江大学化学工程与生物工程学院，工学博士后

2008 -2013年，美国弗吉尼亚大学医学院，医学博士后

2013-至今，杭州师范大学医学院，任教

二、  教研项目

1. miRNA-124在神经小胶质细胞中调控Aβ降解的作用和机制研究，国家自然科学基金青年项目(81300262)，2014 -2016，主持 23万

2. miRNA-124治疗阿尔茨海默氏症研究，浙江省钱江人才项目，2015-2018，主持5万

三、  主要成果（论著、专利、获奖、其他）

1. Jia M, Liu WX, Sun HL, Chang YQ, Yang JJ, Ji MH, Yang JJ, Feng CZ. Suberoylanilide Hydroxamic Acid, A Histone Deacetylase Inhibitor, Attenuates Postoperative Cognitive Dysfunction in Aging Mice. Front. Mol. Neurosci. 2015.8:52.

2. Wang Z, Feng C (co-first author), Zhao H, Ren X, Peng S, Zuo Z. Autoregulation of inducible nitric oxide synthase expression by RNA interference provides neuroprotection in neonatal rats. Theranostics. 2015, 5(5):504-14.

3.  Feng C, Zhang Y, Yin J, Li J, Abounader R, Zuo Z. Regulatory factor X1 is a new tumor suppressive transcription factor that acts via direct downregulation of CD44 in glioblastoma.  Neuro Oncol. 2014, 16(8)：1078-85.

4.  Feng C, Zuo Z. Regulatory factor X1-induced down-regulation of transforming growth factor β2 transcription in human neuroblastoma cells. J Biol Chem. 2012, 287(27): 22730-9.

5.  Cao L, Feng C (co-first author), Li L, Zuo Z. Contribution of microRNA-203 to the isoflurane preconditioning-induced neuroprotection. Brain Research Bulletin. 2012, 88(5): 525-8.

6.   Feng C, Cao L and Zuo Z. RNA interference-produced autoregulation of inducible nitric oxide synthase expression. FEBS Lett.  2011, 585(15): 2488-92.

7. Feng C, Li J and Zuo Z. Expression of the transcription factor regulatory factor X1 in mouse brain. Folia Histochem Cytobiol. 2011, 492(2): 344-51.

8.  Feng C, Xu W and Zuo Z. Knockout of the regulatory factor X1 leads to early embryonic lethality. Biochem Biophys Res Commun. 2009, 386(4): 715-7.

9.   Yin J, Li H, Feng C, Zuo Z. Inhibition of brain ischemia-caused notch activation in microglia may contribute to isoflurane postconditioning-induced neuroprotection in male rats. CNS Neurol Disord Drug Targets. 2014, 13(4):718-32.

10.  Deng J, Zhang J, Feng C, Xiong L, Zuo Z. Critical role of matrix metalloprotease-9 in chronic high fat diet-induced cerebral vascular remodeling  and increase of ischaemic  brain injury in mice. Cardiovasc Res. 2014, 103(4): 473-84.

11.  Deng J, Li J, Li L, Feng C, Xiong L, Zuo Z. Glutamate transporter type 3 knockout leads to decreased heart rate possibly via parasympathetic mechanism. Transgenic Res. 2013, 22(4):757-66.

12.  Li H, Yin J, Li L, Deng J, Feng C, Zuo Z. Isoflurane postconditioning reduces ischemia-induced nuclear factor-κB activation and interleukin 1β production to provide neuroprotection in rats and mice. Neurobiol Dis. 2013, 54:216-24.

13.  Li J, Sheng W, Feng C, Zuo Z. Pyrrolidine dithiocarbamate attenuates brain Aβ increase and improves long-term neurological outcome in rats after transient focal brain ischemia. Neurobiol Dis. 2012, 45(1): 564-72.

14.  Lin D, Feng C, Cao M and Zuo Z. Volatile anesthetics may not induce significant toxicity to human neuron-like cell. Anesth Analg. 2011, 112(5): 1194-8.

15.  Feng CZ, Ding X, Li Y, Chen S, Yang F, Yang WJ. DNA methyltransferase 2 gene in the prawn Macrobrachium rosenbergii: Characteristics and expression patterns during ovary and embryo development. 2007. Zool Sci 24:1059-65.

16.   Li Y, Ma WM, Dai JQ, Feng CZ, Yang F, Ohira T, Nagasawa H, Yang WJ. Inhibition of a novel sperm gelatinase in prawn sperm by the male reproduction-related kazal-type peptidase inhibitor. 2008. Mol Rep Dev 75(8): 1327-37.

17.   Zhu XJ, Feng CZ, Dai ZM, Zhang RC Yang WJ. Characterization of two Artemia AMPA alpha subunit genes: differentially expressed during development and in response to stresses. 2007. Stress 10(1): 53-6.

18.   Feng CZ, Zhu XJ, Dai ZM, Liu FQ, Xiang JH, Yang WJ. Identification of a novel DNA methyltransferase 2 from the brine shrimp, Artemia franciscana. 2007. Comp Biochem Physiol B Biochem Mol Biol 147(2): 191-8.

19.   Feng CZ, Feng Shi. Recent advance in MicroRNA. 2004. Chin J Cell Biol 26:358-88.

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