男（1957-），澳大利亚籍，

phone: 0571-28861708

E-mail: jun-ping.liu@hznu.edu.cn

地址：浙江省杭州市文一西路1378号杭州师范大学科技园D座620,310000

1977年-1980年，白求恩医科大学      临床医学，学士

1982年-1985年，白求恩医科大学      内分泌学，硕士

1987年-1992年，澳大利亚 蒙纳仕大学     神经内分泌，博士

1985年-1987年      北京大学医学部附属第三医院，医生

1992年-1994年  澳大利亚 John Hunter 医院

1995年-1995年  澳大利亚Mater Misericordiae 医学院

1996年-2000年  澳大利亚 贝克医学研究院

2001年-2001年  高级研究员，澳大利亚医学研究总署

2002年-2010年     蒙纳仕大学医学院

2011.1-   杭州师范大学衰老研究所所长、教授

2012.1-   科技部国家重大科学研究项目首席科学家

2014.6-   国家重大研究计划衰老研究领域专家组组长

2014.6-   国家自然科学基金委医学部十三五规划老年医学专家组组长

2011.3-   墨尔本大学遗传学系教授

2013.1-   澳大利亚Monash大学免疫系教授

2000.7-   北京大学客座教授

2013.7-   国际临床实验药理学生理学杂志（CEPP）主编/总编辑

2009.1-   国际自然界药物前沿(Frontiers in Pharmacology of Natural Products)杂志社副主编,

2004.1-   国际神经通讯(Neuroscience Bulletins)编委

2003.1-   中华病理学杂志海外编委, 从2003年1月

2012.6-   杭州端丽生物技术有限公司董事长

2013.7-   杭州市老年医学重点学科学科带头人

2013.10-  中国老年学学会衰老与抗衰老科学委员会副主任委员

2012.1-   杭州市海外人才工作顾问

获奖情况：

2012    杭州市全球引才“521”计划创业创新团队奖

2012    浙江省千人计划特聘教授

2011    杭州市全球引才“521”计划第一批入选者（杭州市千人计划）

2009  ASBMB Beckman Coulter Discovery Science Award澳大利亚生化、分子生物学协会科学发现奖(唯一华人获奖者).

1998  International Society for Preventive Oncology Travel Grant award to the 4th International Symposium “Impact of Biotechnology on Cancer: Prediction, Prevention & Treatment”, Nice (France).

1997  International Young Scientist Fellowship to the 17th International Congress of Biochemistry and Molecular Biology, San Francisco and the International Young Scientist Program, Asilomar, Monterey (USA), by International Union of Biochemistry and Molecular Biology and American Society for Biochemistry & Molecular Biology.

1996 Servier Award by the Endocrine Society of Australia, for the best published work in the previous year by a member of the Endocrine Society of Australia.

1996 International Society for Endocrinology travel award to the 10th International Congress of Endocrinology, San Francisco (USA).

1996  Queen Elizabeth II Research Fellowship 英女皇二世研究员奖

1996 Australian Life Sciences Research Award 1995, for outstanding contribution to life science research: Instigations into the structure and function of the nerve terminal protein dynamin, presented by the Australian Society of Medical Research, Today’s Life Science and Beckman Instruments. 当代生命科学奖(唯一华人获奖者)

1995  International Society for Neurochemistry travel award to the 15th International Society for Neurochemistry Biennial Meeting, Kyoto (Japan).

1995 AW Campbell award for excellence in Neuroscience, by the Australian Neuroscience Society. 澳州神经协会A W Campbell杰出成就奖(唯一华人获奖者)

1995 Inaugural NARF Post-doctoral Investigator Award, by the National Association of Research Fellows, National Health & Medical Research Council of Australia. 首次澳大利亚联邦政府博士后奖(唯一华人获奖者)

1995 Award for the best presentation at the 2nd Youth National Congress of China Association of Science and Technology, by China Association of Science and Technology, Beijing (China). 全国科协青年第二届大会最佳海外报告奖

1994 Award for Scientific Exchange with Taiwan, the Australian Academy of Science and the Australian Academy of Technological Sciences and Engineering, Canberra.

1993 International Society for Neurochemistry travel award to the 14th International Society for Neurochemistry Biennial Meeting and the Advanced School of Neurochemistry 1st Biennial Course on Neurochemistry, Montpellier (France).

1987 Postgraduate Medical Research Fellowship, by Prince Henry's Institute of Medical Research, Melbourne.

回国后主持科研基金：

1. “端粒相关蛋白对人类重大疾病作用机制的研究”，国家“973”重大科研项目，2012-2016，1350万元，首席科学家

2. “ATP13A2对C型尼曼-皮克病细胞代谢及衰老的作用”，国家自然科学基金面上项目，2012-2015，65万元；项目主持人

3. “雌激素在卵巢颗粒细胞肿瘤中作用机制的研究”，国家自然科学基金面上项目，2013-2016，60万元；项目主持人

4. “第四届中国、澳大利亚生物医学研究大会暨2013国际衰老生物学和衰老性疾病研究”，国家自然科学基金面上项目国际合与交流项目，2013，8万元；项目主持人

5. 2012抗衰老研究国际学术交流项目”，浙江省自然科学基金学术交流项目，3万元；项目主持人

6.“老年科学发展战略研究”，国家自然科学基金应急项目，5万元；项目主持人

7. 抑癌基因FBW7在TGF-β引起肺上皮衰老中的角色，国家自然科学基金重点项目，2016-2020，327.6万元；项目主持人

主要成绩：

2011年1月全职回国，现任杭州师范大学衰老研究所所长，国家科技部973首席科学家，澳大利亚华人生物医学协会主席，国际临床和实验生理学药理学杂志主编等。入选杭州市全球引才“521”计划，浙江省千人计划特聘教授。

在国际书刊杂志发表科学论文、综述等100余篇，包括Science、Nature和PNAS。主持澳大利亚科学研究项目20余项，主持科技部国家重大研究项目及国家自然科学基金3项。获澳大利亚七项主要科学研究奖。近来在衰老发生机制研究中，发现 “压力胁迫和能量代谢如何引发过早衰老”的机制，以杭州师范大学为第一作者单位，发表在PNAS上。

建立杭州师范大学衰老研究所，专业研究生物的衰老过程与调控机制。引进了十位教授作为学科带头人负责研究所十个实验室的发展，建设了国内一流、国际领先的医学生物学平台。率领研究所获得杭州市“521”创新团队。

2011年率领杭州师范大学在内的五所大学获得科技部国家973重大科学研究计划项目并任首席科学家。成立杭州端丽生物技术有限公司。

回国后发表SCI文章33篇：

1.  Chen R, Zhang K, Chen H, Zhao X, Wang J, Li L, Cong Y, Ju Z, Xu D, Williams BR, Jia J, Liu JP (2015) Telomerase Deficiency Causes Alveolar Stem Cell Senescence-associated Low-grade Inflammation in Lungs. J Biol Chem, 290(52):30813-29

2.  Zhiguo Wang, Ruping Chen, Ling Hou, Jianfeng Li, Jun-Ping Liu* (2015) Molecular Dynamics and Principal Components of Potassium Binding with Human Telomeric Intra-molecular G-Quadruplex. Protein & Cell, in press (Accepted on Mar. 09 2015) (IF=3.036)

3.  Jun-Ping Liu, Ruping Chen (2015) Stressed SIRT7: facing a crossroad of senescence and immortality. Clinical and Experimental Pharmacology and Physiology, 42 (6): 567-9 (IF=2.405)

4.  Zhiguo Wang, Jun-Ping Liu (2015) Characterization of Potassium binding with human telomeres. Clinical and Experimental Pharmacology and Physiology，42 (9): 902-9. (IF=2.405)

5.  Jian-Feng Li, Jian Li, Zhi-Guo Wang, Hong-Zhen Liu, You-Long Zhao, Jin-Xi Zhang, Shuang-Quan Zhang, Jun-Ping Liu (2015) Identification of interferon-gamma-inducible-lysosomal thiol reductase (GILT) gene in goldfish (Carassius auratus) and its immune response to LPS challenge. Fish & Shellfish Immunology, 42(2), pp 465-472

6.  Lingling Zhang, Leiming Liu, Zhiyong He, Guangbing Li, Junping Liu, Zhangfa Song, Hongchuan Jin, Karl Lenhard Rudolph, Huayu Yang, Yilei Mao, Lianfeng Zhang, Hongbing Zhang, Zhicheng Xiao andZhenyu Ju (2015) Inhibition of wild-type p53-induced phosphatase 1 promotes liver regeneration in mice by direct activation of mammalian target of rapamycin. Hepatology, 61(6): 2030-41. doi: 10.1002/hep.27755. [Epub ahead of print]) (IF=12.003)

7.  Zhiyang Chen, Weiwei Yi, Yohei Morita, Hu Wang, Yusheng Cong, Jun-Ping Liu, Zhicheng Xiao, Karl Lenhard Rudolph, Tao Cheng, Zhenyu Ju (2015) Wip1-deficiency impairs hematopoietic stem cell function via p53 and mTORC1 pathways. Nature Communications, 6:6808. doi: 10.1038/ncomms7808. (IF= 11.47) http://www.ncbi.nlm.nih.gov/pubmed/25879755.

8.  Ruijuan Sun, Heqi Cao, Xudong Zhu, Jun-Ping Liu, Erdan Dong (2015) Current aging research in China. Protein & Cell, 6(5): 314-21. (IF= 3.247)

9.  Anthony J. Sadler, Bandar A. Suliman, Liang Yu, Xiangliang Yuan, Die Wang, Aaron T. Irving, Soroush T. Sarvestani1, Ashish Banerjee, Ashley S. Mansell, Jun-Ping Liu, Steve Gerondakis, Bryan R. G. Williams, Dakang Xu (2015) The acetyltransferase HAT1 moderates the NF-kB response by regulating the transcription factor PLZF. Nature Communications, 6: 6795. doi: 10.1038/ncomms7795. (IF= 11.47)

10.  Anthony J Sadler, Fernando J Rossello, Liang Yu,James A Deane, Xiangliang Yuan, Die Wang, Aaron T Irving, Maria Kaparakis-Liaskos, Michael P Gantier, Hangjie Ying, Howard C. H. Yim, Elizabeth L Hartland, Amanda J Notini, Suzan de Boer, Stefan White, Ashley Mansell, Jun-Ping Liu, David Neil Watkins, Steve Gerondakis, Bryan RG Williams, Dakang Xu (2015) The BTB-ZF transcriptional regulator, PLZF, modifies chromatin to restrain inflammatory signaling programs. Proc Natl Acad Sci U S A, 112(5): 1535-40. (IF= 9.771)

11. Jun-Ping Liu (2014) Aging and related diseases: research progress. Prog. Biochem. Biophys. 41(3): 215-230 (In Chinese)

12. Kexiong Zhang, Chengshu Chen, Yingying Liu, Hao Chen, Jun-Ping Liu (2014) Cellular senescence occurred widespread to multiple selective sites in the fetal tissues and organs of mice. Clinical and Experimental Pharmacology and Physiology, 41(12): 965–975. (IF=2.405)

13. Yin-Li Zhang, Yan Xia, Chao Yu, JoAnne S. Richards, Jun-Ping Liu, Heng-Yu Fan (2014) CBP-CITED4 is required for luteinizing hormone-triggered target gene expression during ovulation. Molecular Human Reproduction, 20 (9): 850–860. (IF= 3.483)

14. Qibin Jiao, Atsushi Sanbe, Xingwei Zhang, Jun-Ping Liu, Susumu Minamisawa (2014) aB-Crystallin R120G variant causes cardiac arrhythmias and alterations in the expression of Ca2+ handling proteins and ER stress in mice. Clinical and Experimental Pharmacology and Physiology, 41(8): 589-599. (IF=2.405)

15. Jun-Ping Liu (2014) Molecular mechanisms of aging and related diseases. Clinical and Experimental Pharmacology and Physiology, 41(7): 445-58. (IF=2.405)

16. Guo Li, Hui-qian Wang, Li-hui Wang, Ru-ping Chen, Jun-Ping Liu (2014) Distinct Pathways of ERK1/2 Activation by Hydroxy-Carboxylic Acid Receptor-1. PLoS One, 9(3):e93041. (IF=3.5)

17. Qian Li, Lin Bai, Ning Liu, Miao Wang, Jun-Ping Liu, Pingsheng Liu and Yu-Sheng Cong (2014) Increased polymerase I and transcript release factor (Cavin-1) expression attenuates platelet-derived growth factor receptor signalling in senescent human fibroblasts. Clinical and Experimental Pharmacology and Physiology, 41(3): 169-73. (IF=2.405)

18. Yan-Cong Li, Shu-Ming He, Zhi-Xu He, Minghua Li, Yinxue Yang, Jian-Xin Pang, Xueji Zhang, Kevin Chow, Qingyu Zhou, Wei Duan, Zhi-Wei Zhou, Tianxin Yang, Gui-Hua Huang, Aibing Liu, Jia-Xuan Qiu, Jun-Ping Liu, Shu-Feng Zhou (2014) Plumbagin induces apoptotic and autophagic cell death through inhibition of the PI3K/Akt/mTOR pathway in human non-small cell lung cancer cells. Cancer Letters, 344(2): 239-59 (IF=4.238)

19. Jun-Ping Liu (2013) A turning point: focusing on translational medicine. Clinical and Experimental Pharmacology and Physiology, 40 (8):485-488. (IF=2.19)

20. Xiangliang Yuan, Liang Yu, Junhua Li, Guohua Xie, Tingting Rong, Liang Zhang, Jianhua Chen, Qiaohong Meng, Aaron T. Irving, Die Wang, Elizabeth D. Williams, Jun-Ping Liu, Anthony J. Sadler, Bryan R.G. Williams, Lisong Shen, and Dakang Xu (2013) Suppression of bladder cancer metastasis by Transcription factor ATF3 regulates gelsolin mediated actin cytoskeleton remodelling. Cancer Research, 73(12): 3625-37 (IF=7.8)

21. Yanhui Ma, Xiangliang Yuan, Lin Deng, Weiping Xu, Yingxia Zheng, Chaoyan Yue, Guanghui Zhang, Fang Xie, Yuan H Yang, Michael P Gantier, Jun-Ping Liu, Dakang Xu, Lisong Shen (2013) Imbalanced frequencies of Th17 and Treg cells in acute coronary syndromes are mediated by IL-6-STAT3 signaling. PLoS One. 2013 Aug 26;8(8):e72804. doi: 10.1371/journal.pone.0072804. (IF=3.7)

22．Edwin Leeansyah, Paul U Cameron, Ajantha Solomon, Pushparaj Velayudham, Maelenn Gouillou, Tim Spelman, Anna Hearps, Christopher Fairley, De Villiers Smit, Anna Pierce, Jude Armishaw, Suzanne M Crowe, David A Cooper, Kersten K Koelsch, Jun-Ping Liu, John Chuah, and Sharon R. Lewin (2013) Inhibition of telomerase activity by HIV Nucleos(t)ide Reverse Transcriptase Inhibitors : a potential factor contributing to HIV-associated accelerated ageing. The Journal of Infectious Diseases, 207 (7): 1157-65 (IF=6.41).  DOI:10.1093/infdis/jit006

23. Peng Xi, Lili Zhou, Miao Wang, Jun-Ping Liu and Yu-Sheng Cong (2013) Serine/threonine-protein phosphatase 2A physically interacts with human telomerase reverse transcriptase hTERT and regulates its subcellular distribution. Journal of Cellular Biochemistry, 114(2): 409–417. (IF= 2.868)

24. Yingxia Zheng, Zhihao Wang, Lin Deng, Xiangliang Yuan, Yanhui Ma, Guanghui Zhang, Michael P. Gantier, Jun-Ping Liu, Lisong Shen, Dakang Xu.(2012) Osteopontin promotes inflammation in patients with acute coronary syndrome through its activity on IL-17 producing cells. Eur J Immunol. 42(10): 2803–2814 (IF=5.1)

25. Craig Nicholls, Alexander Ruvantha Pinto, He Li, Ling Li, Lihui Wang, Richard Simpson, and Jun-Ping Liu (2012) Glyceraldehyde-3-phosphate dehydrogenase (GAPDH) induces cancer cell senescence by interacting with telomerase RNA component. Proc Natl Acad Sci U S A, 109(33): 13308-13. (IF=10.1073)

26. Jun-Ping Liu, Jiake Xu (2012) Introduction: Understanding the signalling mechanisms in molecular physiology and diseases. Clin Exp Pharmacol Physiol; 39:658-60. (IF=2.19)

27. Craig Nicholls, He Li, Jun-Ping Liu (2012) GAPDH: a common enzyme with uncommon functions. Clin Exp Pharmacol Physiol, 39:674-9. (IF=2.19)

28. Craig Nichools, He Li, Jian-Qiu Wang, Jun-Ping Liu (2011) Molecular regulations of telomerase in aging. Protein & Cell, 2(9): 726-38.

29. Ya-He Liu, Sui-Lin Mo, Hui-Chang Bi, Bin-Fang Hu, Chun Guang Li, Yi-Tao Wang, Ling Huang, Min Huang, Wei Duan, Jun-Ping Liu, Ming Qian Wei, Shu-Feng Zhou (2011) Regulation of human pregnane X receptor and its target gene cytochrome P450 3A4 by Chinese herbal compounds and a molecular docking study. Xenobiotica, 41(4): 259-280. (IF = 2.8)

30. Shi-Ming Chen, Jun-Ping Liu, Jun-Xu Zhou, Chen Chen, Yu-Qin Deng, Yan Wang and Ze-Zhang Tao (2011) Suppression of the Notch Signaling Pathway by γ–Secretase Inhibitor GSI Inhibits Human Nasopharyngeal Carcinoma Cell Proliferation. Cancer Letters, 306: 76-84 (IF=3.74)

31. Sharyn Bayne, He Li, Margaret E.E. Jones, Alex R. Pinto, Michelle van Sinderen, Ann Drummond, Evan R. Simpson and Jun-Ping Liu (2011) Estrogen deficiency reversibly induces telomere shortening in mouse granulosa cells and ovarian aging in vivo. Protein & Cell, 2: 333-346

32. Huseyin Sumer, Craig Nicholls, Jun Liu, Pollyanna A. Tat, Jun-Ping Liu and Paul J. Verma (2011) Comparison of reprogramming ability of mouse ES and iPS cells measured by somatic cell fusion. Int J Dev Biol 54: 1723-1728. (IF=3.27)

33. Alex Pinto, He Li Craig Nicholls and Jun-Ping Liu (2011) Telomere protein complexes and interactions with telomerase in telomere maintenance. Frontiers in Bioscience, 16, 187-207 (IF=3.3).