王沥，女，1962年5月生，北京人，
Phone: 0571-28861667(0) Fax: 0571-28861667
E-mail: liwang@hznu.edu.cn
地址：浙江省杭州市文一西路1378号杭州师范大学科技园D505，杭州，311121

1978.9-1983.6 中国科技大学生物系学士

1983.9-1987.6，中国科学院遗传研究所，研究实习员

1987.9-1989.6，美国迈阿密大学，助理研究员

1990.9-1992.6，日本东京大学医学部硕士

1992.9-1995.6，日本东京大学医学部博士

1995.9-1998.6，日本红十字社中央血液研究中心研究部，博士后

1996.9-1998.11，日本东京大学，理学部人类学系，外国人研究员

1998.11-2012.8，中国科学院遗传与发育生物学研究所，研究员

2012/9-至今，杭州师范大学，医学院衰老研究所，教授

科研项目

1. 单基因聋病的分子流行病学研究，科技部“973”课题，项目编号2014CB541701，2014-2018，448万，主持（在研）；

2. 动脉粥样硬化及相关疾病的分子遗传学研究，浙江省自然科学基金重点项目，项目编号LZ13H020001，2013-2016，30万元，主持（在研）；

3. 贾湖古稻分子生物学研究，国家自然科学基金面上项目，项目编号31071058，2011-2013, 35万，主持（已结题）；

4. 保密项目，科技部国家科技支撑计划，项目编号2009BAI85B00，2009-2013, 100万，主持（已结题）；

5. 史前古稻分子生物学研究，国家自然科学基金面上项目，项目编号30870174，2009-2009，8万，主持（已结题）；

6. 分子遗传学，国家自然科学基金杰出青年项目，项目编号30225019，2003-2006，100万，主持（已结题）；

7. 古DNA技术在中国栽培稻起源演化中的应用研究，国家自然科学基金面上项目，项目编号30370761，2004-2004，7万，主持（已结题）；

8. 安阳殷墟及临溜古人类分子遗传学研究，国家自然科学基金面上项目，项目编号39970400，2000-2002，14万，主持（已结题）；

9. 安阳殷墟及临淄古人类分子遗传学研究，国家自然科学基金专项基金项目，项目编号39940003，1999-1999，5万，已结题，主持（已结题）；

主要成绩

个人主要获奖

1、入选中国科学院“百人计划”，1998年

2、获中国科学院“引进国外杰出人才”基金，1999年

3、获得“国家杰出青年科学基金”，2002年

4、入选“首批新世纪百千万人才工程”国家级人选，2004年

5、成为中央组织部备案高层次专家，享受国务院颁发的政府特殊津贴，2005年

6、获民革北京市委突出贡献奖，2009年

7、成为国家高层人才库备案高层次生物和医药人才，2010年

8、浙江省“钱江学者”，2012年

9、浙江省151人才工程导师库，2013年

10、获杭州市全球引才“521”计划人才，2014年

论文专著

1.        Jun Gojobori, Fuzuki Mizuno, Li Wang, Keisuke Onishi, Julio Granados, Celta Gomez-Trejo, Víctor Acuña-Alonzo and Shintaroh Ueda (2015). mtDNA diversity of the Zapotec in Mexico suggests a population decline long before the first contact with Europeans. Journal of Human Genetics 60, 557-559.

2.        Rong Jingjing, Zheng Houfeng, Liu Ming, Hu Xu, Wang,Tao, Zhang,Xingwei, Jin Feng, Wang Li* (2015) Probiotic and anti-inflammatory attributes of an isolate Lactobacillus helveticus NS8 from Mongolian fermented koumiss. BMC Microbiology. 15(1):196.

3.        Zheng HF, Rong JJ, Liu M, Han F, Zhang XW, Richards JB, Wang L. (2015) Performance of Genotype Imputation for Low Frequency and Rare Variants from the 1000 Genomes.PLoS One 10(1):e0116487.

4.        Bi-Rong Guo,Jing-Jing Rong,Yi-Hua Wei ,Wen-Ying Zhong,Cong-Sheng Li,Ming Liu,Wei Li,Xiao-Bo Wang,Li Wang,Hou-Feng Zheng (2015). Ethnicity-stratified analysis of the association between IL-18 polymorphisms and systemic lupus erythematosus in a European population: a meta-analysis. Archives of Dermatological Research. 307(8):747-55.

5.        Fuzuki Mizuno, Jun Gojobori, Li Wang, Keisuke Onishi, Saburo Sugiyama, Julio Granados, Celta Gomez-Trejo, Víctor Acuña-Alonzoand Shintaroh Ueda,(2014) Complete mitogenome analysis of indigenous populations in Mexico: Its relevance for the origin of Mesoamericans. Journal of Human Genetics 59, 359-367.

6.        Hu Xu，Wang Tao，Luo Jia，Liang Shan，Li Wei，Wu Xiaoli，Jin Feng*，Wang,Li* (2014) Age-dependent effect of high cholesterol diets on  anxiety-like behavior in elevated plus maze test in rats. Behavioral and Brain Functions. 10:30.

7.        Makio Kihana, Fuzuki Mizuno，Rikai Sawafuji, Li Wang*, Shintaroh Ueda (2013). Emulsion PCR-coupled target enrichment: an effective fishing method for high-throughput sequencing of poorly preserved ancient DNA. Gene 528(2), 347-351.

8.        Hu Xu, Wang Tao, Jin Feng, Wang Li* (2013). Effects of NS lactobacillus strains on lipid metabolism of rats fed a high-cholesterol diet. Lipids in Health and Disease.12: 67.

9.        Shi X., Wang L., Jin F., Sun J., Sun L., Tang L., Yang Z. (2011). TheENPP1 K121Q polymorphism is not associated with type 2 diabetes in northern Chinese. Acta Diabetol. Mar 31..               

10.     Kumagai M, Wang L, Ueda S. (2010). Genetic diversity and evolutionary relationships in genus Oryza revealed by using highly variable regions of chloroplast DNA. Gene 462(1-2):44-51                                         

11.     Qu Y., Yang Z., Jin F., Sun L., Tang L, Zhang C, Zhu X, Shi X, Sun H, Wang B, Wang B., *Wang L.(2008) The Ser311Cys variation in the paraoxonase 2 gene increases the risk of type 2 diabetes in northern Chinese. J Genet. 87(2):165-169. 

12.     Qu Y., Yang Z., Jin F., Sun L., Tang L, Zhang C, Zhu X, Shi X, Sun H, Wang B, Wang B., *Wang L. (2008) The haplotype identified in LEPR gene is associated with type 2 diabetes mellitus in Northern Chinese. Diabetes Research and Clinical Practice81(1):33-7.                                                        

13.     Shi X., Wang L., Jin F., *Yang Z. (2007) Effect of exercise on gene expression profiles of skeletal muscle in mouse with type 2 diabetes. Chinese Journal of Geriatrics 26(8): 611-615.

14.     Shi X., Jin F., Wang L., *Yang Z. (2007) Association of SNPs-11377C/G in proximal promoter region of adiponectin gene with type 2 diabetes in Northern Chinese Han population. Journal of Clinical Rehabilitative Tissue Engineering Research 11(25) 4941-4944.

15.     Qu Y., Yang Z., Jin F., Sun L., Zhan C., Sun H., Wang B., *Wang L. (2007) Analysis of the relationship between three coding polymorphisms in LEPR gene and obesity in Northern Chinese. Obesity Research & Clinical Practice1: 261-266.

16.     Wang B, Jin F, Yang Z, Zheng C, Lu Z. *Wang L. (2007) HSPG2 gene C/A polymorphism do not confer susceptibility to Alzheimer’s disease in Chinese. Dementia and Geriatric Cognitive Disorders 23(5):312-315.

17.     Wang B., Jin F., Xie Y., Tang Y., Kan R., Zheng C., Yang Z., *Wang L. (2006) Association analysis of NAD(P)H:quinone oxidoreductase gene 609 C/T polymorphism with Alzheimer's disease. Neurosci Letters. 409(3):179-81.

18.     Wang B., Jin F., Yang Z., Lu Z., Kan R., Li S., Zheng C., *Wang L. (2006) The insertion polymorphism in angiotensin-converting enzyme gene associated with the APOE epsilon 4 allele increases the risk of late-onset Alzheimer disease. Journal of Molecular Neuroscience 30(3):267-71.                              

19.     Wan C., Zhang T., Wang B., Han Y., Zhang C., Zhang Y., Gong H., *Jin F.,*Wang L. (2006) Obesity risk associated with the K121Q polymorphism of the glycoprotein PC-1 gene. Diabetes, Obesity and Metabolism 8(6):703-8.           

20.     Sun L., *Yang Z., Jin F., Zhu X., Qu Y., Shi X., *Wang L. (2006) The Gly482Ser variant of the PPARGC1 gene is associated with Type 2 diabetes mellitus in northern Chinese, especially men. Diabetic Medicine 23(10):1085-92.   

21.     Kurosaki T., Ninokata A., and Wang L., and *Ueda S. (2006) Evolutionary scenario for acquisition of CAG repeats in human SCA1 gene.Gene373:23-7.

22.     Wan C., Yang Y., Feng G., Gu N., Liu H., Zhu S., *He L., and *Wang L. (2005) Polymorphisms of myelin-associated glycoprotein gene are associated with schizophrenia in the Chinese Han population. Neuroscience Letters 388(3):126-131.

23.     Wang B., Jin F., Kan R., Ji S., ZhangC., LuZ., ZhengC., YangZ., and *WangL.(2005)Association of MTHFRgene polymorphism C677T with susceptibility to late-onset Alzheimer’s disease. Journal of Molecular Neuroscience27(1):23-27.

24.     Kurosaki K., WangL., TangJ., WangW.,SaitouN., EndoT. and UedaS. (2005) Identification of a bronze weapon based on an embedded fragmentin a 3,000-year-old skull. Forensic Science International 151(1): 105-108.

25.     KanR., WangB., ZhangC., JinF., ZhengW., LuZ., ZhengC., YangZ. and *WangL. (2005) Genetic association of BACE 1 gene polymorphism C786G with late-onset Alzheimer’s disease in Chinese. Journal of Molecular Neuroscience25(2):127-131.

26.     KanR., WangB., ZhangC., YangZ.,ZhengW.,LuZ., ZhengC.,*JinF. and*WangL. (2004) Association of the HTR6polymorphism C267T with late-onset Alzheimer’s disease in Chinese. Neuroscience Letters 372(1-2): 27-29.  

27.     WangB., ZhangC., ZhengW., LuZ., ZhengC., YangZ., WangL. and *JinF. (2004)Association between a T/C polymorphism in intron 2 of cholesterol 24S-hydroxylase gene and Alzheimer's disease in Chinese. Neuroscience Letters 369(2):104-107.

28.     Kan R., Twigg S.R., Berg J., Wang L., Jin F., and Wilkie A.O. (2004) Expression analysis of an FGFR2 IIIc 5' splice site mutation (1084+3A➝G). Journal of Medical Genetics 41(8):e108.                                                         

29.     Zhang P., Yang Z., Wan C., Zheng W., Zhang C., Zheng C., *Jin F.,and Wang L. (2004) Neither the Tumor Necrosis Factor -308 A/G Polymorphism nor the 2-Macroglobulin Polymorphism was Associated with Late-onset Alzheimer’s Disease in Chinese.Acta Genetica Sinica 31(1):1-6.

30.     Zhang P., Yang Z., Zhang C., Lu Z., Shi X., Zheng W., Wan C., Zhang D., Zheng C., Li S., *Jin F. andWang L. (2003) Association study between late-onset Alzheimer's disease and the transferrin gene polymorphisms in Chinese.Neuroscience Letters.349(3):209-11.                                                                

31.     Oota H., Kitano T., Jin F., Yuasa I., Wang L., Ueda S., Saitou N., and Stoneking M. (2002) Extreme mtDNA Homogeneity in Continental Asian Populations. American Journal of Physical Anthropology 118(2): 146–153.                        

32.     Wang L., MizunoF. and S. Ueda. Evolutionary Genomics of Transcription Factor Brain-2 in Mammals. (2002) The American Journal of Human Genetics 2002, Supplement to 2002, 71(4): 397. (abstract)                                    

33.     Wang L., N. Saitou and S. Ueda. (2001) Genetic Structure of 2500-year-old Human Population in China. The American Journal of Human Genetics Supplement to 69(4): 34. (abstract)                                                          

34.     Wang L.(2001) Ancient DNA: A Powerful Tool for Tracing Past. Bulletin of the Chinese Academy of Sciences16(4) :263-265.

35.     Wang L., Oota H., Saitou N., Jin F., Matsushita T., and Ueda S. (2000) Genetic Structure of a 2,500-Year-Old Human Populations in China and Its Spatiotemporal Changes. Molecular Biology and Evolution 17(9): 1396-1400.          

36.     *Wang L., Uchikawa M., Tokunaga K., and Juji T. (1998) Molecular Cloning and Characterization of Decay-Accelerating Factor Deficiency in Cromer Blood Group Inab Phenotype.Blood 91(2): 680-684.                                         

37.     *Wang L., Todokoro K., Tokunaga K., Takai K., and Juji T. (1997) Restricted Usage of T-cell Receptor VßGene in Post-transfusion Graft-versus-Host Disease.Transfusion 37(11-12): 1184-1191.                                           

38.     Nakachi Y,Hayakawa T., Oota H., Sumiyama K., Wang L., and Ueda S. (1997)Nucleotide Compositional Constraints on Genomes Generate Alanine-, Glycine-, and Proline-rich Structures in Transcription Factors.Molecular Biology and Evolution14(10): 1042-1049.                                                           

39.     Uchida S., Wang L., Yahagi Y., Tokunaga K., and Juji T. (1996) Utility of Fingernail DNA for Evaluation of Chimerism after Bone Marrow Transplantation and for Diagnostic Testing for Transfusion-Associated Graft-versus-Host Disease. Blood 87(9): 4015-4016.                                                               

40.     Fujiwara K., Tokunaga K., Isa K., Miyamoto M., Wang L., and Juji T. (1995) DNA-Based Typing of Human Platelet Antigen Systems by PCR-SSCP (Single-Strand Conformation Polymorphism) Method.Vox Sanguinis 69(4): 347-351.

41.     Wang QR., Ogura T., and Wang L. (1995) Research and Development on Buckwheat and It's New Products.Current Advanced Research in Buckwheat 2: 873-879.

42.     *Wang L., Juji T., Tokunaga K., Uchida S., Tadokoro K., and Takai K. (1994) Polymorphic Microsatellite Markers for the Diagnosis of Graft-versus-Host Disease.The New England Journal of Medicine 330(6): 398-401.          

43.     Uchida S., Wang L., Tokunaga K., Tadokoro K., and Juji T. (1994) Diagnosis of Post-transfusion Graft-versus-Host Disease. Japanese Journal of Transfusion Medicine 40(1): 142-144.