曾嘉，男，1977年生，博士，特聘教授，硕士生导师，湖南科技大学分子生物学科带头人。2002年毕业于浙江大学获工学硕士学位，2006年毕业于香港城市大学获哲学博士学位。主要研究方向为铁硫蛋白结构与功能，脂肪酸代谢酶的催化机理和结构功能关系，脂肪酸代谢与胰岛素抵抗的关联性研究。主持包括国家自然科学基金，教育部博士点基金，国家基础研究计划子课题，中央高校科研创新项目在内的科研项目10余项。在《Org. Lett.》, 《Biochemistry》, 《Bioorg. Med. Chem. Lett.》, 《Arch. Biochem. Biophys.》, 《FEBS. Lett.》, 《BBA》, 《Process Biochemistry》等主流学术刊物上发表研究论文60余篇，其中被SCI收录40篇，EI收录12篇；申请发明专利3项。已指导培养研究生20人。
1授权PCT国际专利
1. 一种提高线粒体代谢机能的方法及应用，PCT/CN2014/071234，ZL 2014 80002059.2，2016
2承担的部分科研项目
1.国家自然科学基金面上项目(No. 30900024)，项目负责人
2. 教育部博士点基金（No.200805331034），项目负责人
3代表性论文
1. Ye Guo, Lin Tang, Min Wang, Jia Zeng*, Role of His 143 in the electron transfer of Rusticyanin from Acidithiobacillus ferrooxidans. Life Science Research. 2014, 18, 395-400.
2. Hongyu Mo, Qian Chen, Juan Du, Lin Tang, Fang Qin, Jia Zeng*. Ferric reductase activity of the ArsH protein from Acidithiobacillus ferrooxidans. J. Microbiol. Biotechnol. 2011, 21, 464-469 (Featured Article, SCI, IF=2.037)
3. Qian Chen, Hongyu Mo, Lin Tang, Juan Du, Jia Zeng*. Assembly mechanism of the [Fe2S2] cluster in ferredoxin from Acidithiobacillus ferrooxidans. J. Microbiol. Biotechnol. 2011, 21, 124-128. (SCI. IF=2.037)
4. Chenbing Ai, Hongyu Mo, Qian Chen, Yuandong Liu, Lin Tang, Jia Zeng*. Expression, purification and characterization of an iron Chaperon protein CyaY from Acidithiobacillus ferrooxidans. Current Microbiology 2011, 62, 733-738. (SCI, IF=1.423)
5. Jia Zeng*, Qin Liu, Xiaojian Zhang, Hongyu Mo, Yiping Wang, Qian Chen, Yuandong Liu. Functional roles of the aromatic residues in the stabilization of the [Fe4S4] cluster in the Iro protein from Acidithiobacillus ferrooxidans. J. Microbiol. Biotechnol. 2010, 20, 294-300. (SCI. IF=2.037)
6. Yiping Wang, Xiaojian Zhang, Qin Liu, Chenbing Ai, Hongyu Mo, Jia Zeng*. Expression, purification and molecular modeling of thioredoxin and thioredoxin reductase from Acidithiobacillus ferrooxidans. 2009, 59, 35-41. (SCI, IF=1.423)
7. Yunjie Dai, Jianshe Liu, Chunli Zheng, Jia Zeng, Guanzhou Qiu. Cys92, Cys101, Cys197 and Cys203 are crucial residues for coordinating the iron-sulfur cluster of RhdA from Acidithiobacillus ferrooxidans.Current Microbiology 2009, 59, 559-564. (SCI, IF=1.423)
8. Jia Zeng*, Xiaojian Zhang, Yiping Wang, Chenbing Ai, Qing Liu and Guanzhou Qiu. Glu43 is an essential residue for coordinating the [Fe2S2] cluster of IscR from Acidithiobacillus ferrooxidans. FEBS Lett. 2008, 582, 3889-3892. (SCI, IF=3.341)
9. Jia Zeng, Long Wu, Xiaojian Zhang, Yuandong Liu, Guisheng Deng, Ding Li Oct-2-en-4-ynoyl-CoA as a specific inhibitor of acyl-CoA oxidase. Org. Lett. 2008, 10, 4287-4290. (SCI, IF=6.364)
10. Jia Zeng, Ke Zhang, Jianshe Liu, Guanzhou Qiu. Expression, purification and characterization of an Iron-Sulfur cluster assembly regulator IscR from Acidithiobacillus ferrooxidans. J. Microbiol. Biotechnol. 2008, 2008, 18, 1672-1677. (SCI, IF=2.037)
11. Huidan Jiang, Xiaojian Zhang, Chenbin Ai, Yuandong Liu, Jianshe Liu, Guanzhou Qiu, Jia Zeng*. Asp97 is a crucial residue involved in the ligation of the [Fe4S4] cluster of IscA from Acidithiobacillus ferrooxidans. J. Microbiol. Biotechnol. 2008, 18, 1070-1075. (SCI, IF=2.037)
12 Jia Zeng*, Huidan Jiang, Meimei Geng, Yiping Wang, Xiaojian Zhang, Jianshe Liu, Guanzhou Qiu. In vitro Assembly of [Fe4S4] cluster in High Potential Iron-Sulfur Protein from Acidithiobacillus ferrooxidans. Current Microbiology 2008, 57, 161-166. (SCI, IF=1.423)
13. Jia Zeng*, Ming Wang, Xiaojian Zhang, Yiping Wang, Chenbin Ai, Jianshe Liu and Guanzhou Qiu. Expression, purification and characterization of the sulfite reductase hemo subunit, SiR-HP, from Acidithiobacillus ferrooxidans. Biotech. Lett. 2008, 30, 1239-1244. (SCI, IF=1.736)
14. Lexian Xia, Xinxing Liu, Jia Zeng, Chu Yin, Jian Gao, Jianshe Liu, Guanzhou Qiu Mechanism of enhanced bioleaching efficiency of Acidithiobacillus ferrooxidans after adaptation with chalcopyrite. Hydrometallurgy 2008, 92, 95-101 (SCI, IF=2.224)
15. Jia Zeng*, Huidan Jiang, Yuandong Liu, Jianshe Liu, and Guanzhou Qiu. Expression, Purification and Characterization of A High Potential Iron-Sulfur Protein from Acidithiobacillus ferrooxidans. Biotech. Lett. 2008, 30, 905-910. (SCI, IF=1.736)
16. Jia Zeng, Yuandong Liu, Long Wu, Ding Li. Mutation of Tyr375 to Lys375 allows medium-chain acyl-CoA dehydrogenase to acquire acyl-CoA oxidase activity. Biochim. Biophis. Acta. 2007, 1774, 1628-1634. (SCI, IF=5.083)
17. Jia Zeng, Xia Huang, Yuandong Liu, Jianshe Liu, and Guanzhou Qiu. Expression, purification and characterization of a [Fe2S2] cluster containing ferredoxin from Acidithiobacillus ferrooxidans. Current Microbiology 2007, 55:518-523. (SCI, IF=1.423)
18. Jia Zeng, Wenjie Zhao, Yuandong Liu, Lexian Xia, Jianshe Liu, and Guanzhou Qiu Expression, purification and characterization of an Iron-Sulfur cluster assembly protein IscU from Acidithiobacillus ferrooxidans. Biotech. Lett. 2007, 29:1965-1972. (SCI, IF=1.736)
19. Jia Zeng, Yanfei Zhang, Yuandong Liu, Xiaojian Zhang, Leixian Xia, Jianshe Liu, and Guanzhou Qiu. Expression, purification and characterization of a cysteine desulfurase IscS from Acidithiobacillus ferrooxidans. Biotech. Lett. 2007, 29:1983-1990. (SCI, IF=1.736)
20. Lexian Xia, Jia Zeng, Jianlan Ding, Yi Yang, Bo Zhang, Jianshe Liu, and Guanzhou Qiu. Comparison of three induced mutation methods for Acidiothiobacillus caldus in processing sphalerite. Minerals Engineering 2007, 20:1323-1326. (SCI, IF=1.714)
21. Long Wu, Jia Zeng, Guisheng Deng, Fei Guo, Nan Li, Xiaojun Liu, Xiusheng Chu, and Ding Li Inactivation of thiolase by 2-alkynoyl-CoA via its intrinsic isomerase activity. Org. Lett. 2007, 9:3877-3880. (SCI, IF=6.364)
22. Jia Zeng, Meimei Geng, Huidan Jiang, Yuandong Liu, Jianshe Liu, and GuanzhouQiu. The Isc A from Acidithiobacillus ferrooxidans is an iron-sulfur protein which assemble the [Fe4S4] Cluster with intracellular iron and sulfur. Arch. Biochem. Biophys. 2007, 463:237-244. (SCI, IF=3.043)
23. Jia Zeng, Meimei Geng, Yuandong Liu, Lexian Xia, Jianshe Liu and Guanzhou Qiu. The sulfhydryl group of Cys138 of rusticyanin from Acidithiobacillus ferrooxidans is crucial for copper binding. Biochim. Biophis. Acta. 2007, 1774:519-525. (SCI, IF=5.083)
24. Jia Zeng, Meimei Geng, Yuandong Liu, Wenjie Zhao, Lexian Xia, Jianshe Liu, and Guanzhou Qiu. Expression, purification and molecular modeling of the Iro protein from Acidithiobacillus ferrooxidans Fe-1. Protein Expr. Purif. 2007, 52:146-152. (SCI, IF=1.867)
25. Jia Zeng, Guisheng Deng, Wenhua Yu, Ding Li. Inactivation of medium-chain acyl-CoA dehydrogenase by oct-4-en-2-ynoyl-CoA. Bioorganic and Medicinal Chemistry Letters. 2006, 16:1445-1448. (SCI, IF=2.538)
26. Jia Zeng, Guisheng Deng, Ding Li. Intrinsic enoyl-CoA isomerase activity of acyl-CoA oxidase I. Biochim Biophis Acta. 2006, 1760:78-85. (SCI, IF=5.083)
27. Jia Zeng，Ding Li. Intrinsic isomerase activity of medium-chain acyl-CoA dehydrogenase. Biochemistry 2005, 44:6715-6722. (SCI, IF=3.194)
28. Jia Zeng, Ding Li. Expression and purification of his-tagged rat peroxisomal acyl-CoA oxidase I wild-type and E421 mutant proteins. Protein Expr. Purif. 2004, 38: 153-160. (SCI, IF=1.867)
29. Jia Zeng, Ding Li. Expression and purification of His-tagged rat mitochondrial medium-chain acyl-CoA dehydrogenase wild-type and Arg256 mutant proteins. Protein Expr. Purif. 2004, 37:472-478. (SCI, IF=1.867)
30. Jia Zeng, Ding Li. Expression and purification of His-tagged rat mitochondrial 3-ketoacyl-CoA thiolase wild-type and His352 mutant proteins. Protein Expr. Purif. 2004, 35:320-326. (SCI, IF= 1.867)
